The Birds, the Bees, and Innate Immunity

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The Birds, the Bees, and Innate Immunity Glen N. Barber Immunity Volume 46, Issue 4, Pages 521-522 (April 2017) DOI: 10.1016/j.immuni.2017.04.002 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 NLRP14 Inhibits STING-Dependent Innate Immune Signaling during Fertilization Self-DNA is usually absent from the cytoplasm. However, during fertilization, sperm cell-derived DNA enters oocyte cytoplasm and could potentially trigger innate immune signaling pathways to induce cytokine production that could cause tissue damage and infertility. Abe et al. (2017) show that NLRP14 is specifically expressed in germ cells and negatively regulates the nucleic-sensing responses triggered by sperm cell-derived DNA in oocytes. NLRP14 interacts with TBK1 and inhibits STING-dependent cytokine production. Immunity 2017 46, 521-522DOI: (10.1016/j.immuni.2017.04.002) Copyright © 2017 Elsevier Inc. Terms and Conditions