Has the T cell bitten off more than it can chew?

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T cell-mediated immunity Chapter 8

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Has the T cell bitten off more than it can chew? by Gordon Cook Blood Volume 120(10):1966-1967 September 6, 2012 ©2012 by American Society of Hematology

Intercellular transfer of tumor-derived HLA-G and CD86 proves immune-tolerogenic in myeloma. Intercellular transfer of tumor-derived HLA-G and CD86 proves immune-tolerogenic in myeloma. Malignant plasma cells in myeloma induce immune dysfunction by directly inhibiting activation of T cells and dendritic cells as well as indirectly through inducing regulatory T cells. In addition to soluble factors, physical contact including trogocytosis can mediate immune suppression. Professional illustration by Paulette Dennis. Gordon Cook Blood 2012;120:1966-1967 ©2012 by American Society of Hematology