Volume 145, Issue 4, Pages (October 2013)

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Volume 145, Issue 4, Pages 708-711 (October 2013) The Rapid Rise in Gastroesophageal Junction Tumors: Is Inflammation of the Gastric Cardia the Underwater Iceberg? Michael Quante Gastroenterology Volume 145, Issue 4, Pages 708-711 (October 2013) DOI: 10.1053/j.gastro.2013.08.023 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 In a proposed model of Barrett's esophagus (BE), the proximal extension of original cardiac mucosa originates metaplasia in the esophagus. In obese patients, accelerated influx of immune cells and expression of cytokines, as well as an increased intra-abdominal pressure with an increased exposure of bile and gastric acid to the lower esophageal sphincter (LES) likely results in an altered microenvironment at the squamocolumnar junction (SCJ) that induce a lengthening of the cardiac mucosa through an expansion of adjacent cardiac glands. Gastroenterology 2013 145, 708-711DOI: (10.1053/j.gastro.2013.08.023) Copyright © 2013 AGA Institute Terms and Conditions