The apoptotic profile of human cumulus cells changes with patient age and after exposure to sperm but not in relation to oocyte maturity Odette Moffatt,

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Presentation transcript:

The apoptotic profile of human cumulus cells changes with patient age and after exposure to sperm but not in relation to oocyte maturity Odette Moffatt, Ph.D., Sarah Drury, M.Sc., Matthew Tomlinson, Ph.D., Masoud Afnan, M.D., Denny Sakkas, Ph.D. Fertility and Sterility Volume 77, Issue 5, Pages 1006-1011 (May 2002) DOI: 10.1016/S0015-0282(02)02951-5

FIGURE 1 The percentage of cumulus cells (±SEM) positive to Fas, FasL, Bcl-xl, and TIAR in relation to oocyte maturity and when recovered from inseminated fertilized oocytes. Cumulus cells were recovered from 71 MII (white bar), 16 GV and 7 MI (stippled bar), 34 abnormal (shaded bar), and 43 inseminated (solid bar) oocytes. ∗P<.05 indicates significantly different from MII group. Moffatt. Apoptosis in cumulus cells. Fertil Steril 2002. Fertility and Sterility 2002 77, 1006-1011DOI: (10.1016/S0015-0282(02)02951-5)

FIGURE 2 The percentage (±SEM) of TUNEL-positive cumulus cells in relation to oocyte maturity and when recovered from inseminated fertilized oocytes. Cumulus cells were recovered from 71 MII, 16 GV and 7 MI, 34 abnormal, and 43 inseminated oocytes. ∗P<.05 indicates significantly different from MII group. Moffatt. Apoptosis in cumulus cells. Fertil Steril 2002. Fertility and Sterility 2002 77, 1006-1011DOI: (10.1016/S0015-0282(02)02951-5)