Fas-Deficient C3.MRL-Tnfrsf6lpr Mice and Fas Ligand-Deficient C3H/HeJ-Tnfsf6gld Mice Are Relatively Resistant to the Induction of Alopecia Areata by Grafting.

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Fas-Deficient C3.MRL-Tnfrsf6lpr Mice and Fas Ligand-Deficient C3H/HeJ-Tnfsf6gld Mice Are Relatively Resistant to the Induction of Alopecia Areata by Grafting of Alopecia Areata-Affected Skin from C3H/HeJ Mice Pia Freyschmidt-Paul, Kevin J. McElwee, Vladimir Botchkarev, Sabine Kissling, Elke Wenzel, John P. Sundberg, Rudolf Happle, Rolf Hoffmann Journal of Investigative Dermatology Symposium Proceedings Volume 8, Issue 1, Pages 104-108 (June 2003) DOI: 10.1046/j.1523-1747.2003.12182.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 AA can be induced in control mice, but not in Fas-deficient and FasL-deficient mice. AA on the ventral surface of a control mouse (A), no hair loss on the ventral surface of Fas-deficient (B) and FasL-deficient (C) mice 20 wk after induction of AA by skin grafting. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 104-108DOI: (10.1046/j.1523-1747.2003.12182.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Fas-deficient and FasL-deficient skin is resistant to the development of AA. Extensive AA in host skin around the grafts (8 wk after grafting of Fas-deficient and FasL-deficient mouse skin on to mice with extensive AA) contrasts with hair growth from FasL-deficient (left arrow, magnification a) and Fas-deficient (right arrow, magnification b) skin grafts. Control C3H/HeJ skin grafted to AA-affected hosts developed AA within this time period (not shown). 15 mm=100 μm Journal of Investigative Dermatology Symposium Proceedings 2003 8, 104-108DOI: (10.1046/j.1523-1747.2003.12182.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Increased numbers of apoptotic cells are found in C3H/HeJ mice with AA. Immunofluorescence double staining for Fas (red fluorescence) and TUNEL (green fluorescence, indicates apoptotic cells). Only single apoptotic cells in hair follicles of mice without AA (A), increased numbers of apoptotic cells in AA-affected mice (B). Nuclear staining: blue. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 104-108DOI: (10.1046/j.1523-1747.2003.12182.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Virtually no apoptotic cell is present in hair follicles of Fas-deficient and FasL-deficient mice. Absence of TUNEL-positive cells (green fluorescence) in hair follicles of FasL-deficient (left) and Fas-deficient (right) mice. Nuclear staining: blue. 15 mm=100 μm Journal of Investigative Dermatology Symposium Proceedings 2003 8, 104-108DOI: (10.1046/j.1523-1747.2003.12182.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions