Volume 18, Issue 1, Pages 1-2 (July 2015)

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Volume 18, Issue 1, Pages 1-2 (July 2015) Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders Caitlin N. Spaulding, Karen W. Dodson, Matthew R. Chapman, Scott J. Hultgren Cell Host & Microbe Volume 18, Issue 1, Pages 1-2 (July 2015) DOI: 10.1016/j.chom.2015.06.013 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Overview of Autoimmunity Stimulated by Bacterial Amyloid Biofilm Formation eDNA is integrated into the curli biofilm formed by Salmonella typhimurium, increasing the rate of amyloid polymerization and biofilm formation. Subsequently, dendritic cells (DCs) can recognize and phagocytose curli/eDNA composites, stimulating an immunogenic response that leads to the induction of inflammatory cytokines and the production of antinuclear antibodies. The presence of antinuclear antibodies can lead to autoimmune diseases, like lupus. Cell Host & Microbe 2015 18, 1-2DOI: (10.1016/j.chom.2015.06.013) Copyright © 2015 Elsevier Inc. Terms and Conditions