There's No Place Like Home for a Neural Stem Cell

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Presentation transcript:

There's No Place Like Home for a Neural Stem Cell Julie A. Siegenthaler, Samuel J. Pleasure Cell Stem Cell Volume 7, Issue 2, Pages 141-143 (August 2010) DOI: 10.1016/j.stem.2010.07.001 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Diagram of the SVZ Stem Cell Niche Quiescent B cells (Bq) are in a subependymal position with an apical process in contact with the ventricular space. Once activated (Ba), these cells generate transiently amplifying C cells positioned in close proximity to blood vessels. Both the ependyma and vessels express SDF1 that drives the expression of receptors that regulate proliferative behavior (EGFR) and cell adhesion (α6β1). C cells generate A cells, which then migrate to the olfactory bulb via the rostral migratory stream. Cell Stem Cell 2010 7, 141-143DOI: (10.1016/j.stem.2010.07.001) Copyright © 2010 Elsevier Inc. Terms and Conditions