Mean density of CD8+ and Foxp3+ lymphocytes in tumour infiltrate before (pre-TPF) and after (post-TPF) induction chemotherapy, (A) Patients’ tumours with.

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Mean density of CD8+ and Foxp3+ lymphocytes in tumour infiltrate before (pre-TPF) and after (post-TPF) induction chemotherapy, (A) Patients’ tumours with increased expression of CD8+/Foxp3+ lymphocytes after TPF are represented in green; patient’s tumours with stable and decreased expression are depicted in orange and purple, respectively. Mean density of CD8+ and Foxp3+ lymphocytes in tumour infiltrate before (pre-TPF) and after (post-TPF) induction chemotherapy, (A) Patients’ tumours with increased expression of CD8+/Foxp3+ lymphocytes after TPF are represented in green; patient’s tumours with stable and decreased expression are depicted in orange and purple, respectively. At baseline, mean CD8+ lymphocytes density was 237/mm2 and increased after TPF (512/mm2) (P=0.01). At baseline, mean Foxp3+ lymphocytes mean density was 84/mm2 and increased after TPF (164/mm2) (P=0.09). (B) Representative staining images: (a and b) CD8+ lymphocytes before induction chemotherapy (a) increased after induction chemotherapy (b). (c and d) Foxp3+ lymphocytes before induction chemotherapy (c) increased after induction chemotherapy (d). (Virtual Slide VS120-SL microscope (Olympus, Tokyo, Japan), 20× air objective (0.75 NA)). TPF, docetaxel, platinum and fluorouracil. Charlotte Leduc et al. ESMO Open 2018;3:e000257 Copyright © European Society for Medical Oncology. All rights reserved.