This Month in Gastroenterology Jan Tack, John M. Carethers  Gastroenterology  Volume 135, Issue 6, Pages 1827-1830 (December 2008) DOI: 10.1053/j.gastro.2008.11.007 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Results from multivariate analysis showing the odds ratio for colonoscopy-related bleeding or perforation according to the annual colonoscopy volume of the endoscopist. Beside polypectomy, male gender, and older age, a procedure performed by a low-volume endoscopist was also an independent risk factor for these complications. Gastroenterology 2008 135, 1827-1830DOI: (10.1053/j.gastro.2008.11.007) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Outcomes of drug-induced liver injury according to implicated agent, patient age, and pattern. No significant differences were observed in relation to these characteristics. Gastroenterology 2008 135, 1827-1830DOI: (10.1053/j.gastro.2008.11.007) Copyright © 2008 AGA Institute Terms and Conditions

Figure 3 Adenovirus rescue of the glucagon receptor in Gcgr−/− mice attenuates Jo2-induced apoptosis. (A) Fed-state levels of plasma glucagon in Gcgr−/− mice 5 days after intravenous administration of 1 × 109 pfu of either Ad-LacZ (control), or Ad-rGcgr (recombinant glucagons receptor); glucagon levels in nontransduced Gcgr−/− mice are also shown. Data are mean values ± standard error of the mean (n = 6–8 mice per group). ***P < .001, Ad-LacZ versus Ad-Gcgr–transduced Gcgr−/− mice or Gcgr+/+ mice. (B, C). Five days after administration of adenovirus as indicated in A, Gcgr−/− mice were injected with 10 μg Jo2 (n = 6–8 mice per group). After 4 hours, liver samples were taken for analysis. (B) Individual hepatic apoptosis scores were assessed. Horizontal line, median. (C) Immunohistochemical and quantitative detection of cleaved caspase-3 in liver sections from either Ad-LacZ– or Ad-rGcgr–infected Gcgr−/− mice after Jo2 administration (original magnification, 50×). Gastroenterology 2008 135, 1827-1830DOI: (10.1053/j.gastro.2008.11.007) Copyright © 2008 AGA Institute Terms and Conditions