Figure 2 Effect of PPIs on gastric physiology

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Figure 2 Effect of PPIs on gastric physiology Figure 2 | Effect of PPIs on gastric physiology. The pathway of acid impairment by proton-pump inhibitors (PPIs) is illustrated (dotted lines indicate putative pathways). Hypochlorhydria interferes with antral D and G cells, resulting in increased gastrin and chromogranin that activates a hyperplastic reaction in enterochromaffin-like (ECL) cells and parietal cells. Malfertheiner, P. et al. (2017) Proton-pump inhibitors: understanding the complications and risks Nat. Rev. Gastroenterol. Hepatol. doi:10.1038/nrgastro.2017.117