Aspirin and Clopidogrel Resistance

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Presentation transcript:

Aspirin and Clopidogrel Resistance Erin D. Michos, MD, Reza Ardehali, MD, PhD, Roger S. Blumenthal, MD, Richard A. Lange, MD, Hossein Ardehali, MD, PhD Mayo Clinic Proceedings Volume 81, Issue 4, Pages 518-526 (April 2006) DOI: 10.4065/81.4.518 Copyright © 2006 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Sites of action of aspirin and clopidogrel. ADP = adenosine diphosphate; COX-1 = cyclooxygenase 1; GP = glycoprotein; TXA2 = thromboxane A2. Mayo Clinic Proceedings 2006 81, 518-526DOI: (10.4065/81.4.518) Copyright © 2006 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Proposed mechanisms for aspirin resistance. ASA = aspirin; COX = cyclooxygenase; NSAIDs = nonsteroidal anti-inflammatory drugs; TXA2 = thromboxane A2. Mayo Clinic Proceedings 2006 81, 518-526DOI: (10.4065/81.4.518) Copyright © 2006 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 3 Proposed mechanisms for clopidogrel resistance. ACS = acute coronary syndrome. Mayo Clinic Proceedings 2006 81, 518-526DOI: (10.4065/81.4.518) Copyright © 2006 Mayo Foundation for Medical Education and Research Terms and Conditions