Enhanced Dendritic Integration by Ih Reduction in the Anterior Cingulate Cortex Increases Nociception Jasmine R. Dickinson, Grégory Scherrer Neuron

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Enhanced Dendritic Integration by Ih Reduction in the Anterior Cingulate Cortex Increases Nociception Jasmine R. Dickinson, Grégory Scherrer Neuron Volume 86, Issue 1, Pages 4-6 (April 2015) DOI: 10.1016/j.neuron.2015.03.045 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 A Speculative Model of ACC-Enhanced Dendritic Integration and Rescue during Chronic Pain (A) Pain neural pathways. ACC, anterior cingulate cortex; IC, insular cortex; S1, primary somatosensory cortex; S2, secondary somatosensory cortex; PFC, prefrontal cortex; PAG, periaqueductal gray; RVM, rostral ventromedial medulla. (B) Nerve injury reduces Ih, leading to enhanced temporal summation at the soma and increased nociception. (C) 5-HT7 agonism at distal dendrites increases cAMP levels which restores Ih and normal temporal summation, reducing injury-induced hypersensitivity. Neuron 2015 86, 4-6DOI: (10.1016/j.neuron.2015.03.045) Copyright © 2015 Elsevier Inc. Terms and Conditions