Influence of gender and age on course of infection and cytokine responses in mice with disseminated Cryptococcus neoformans infection  O. Lortholary, L. Improvisi, C. Fitting, J.-M. Cavaillon, F. Dromer  Clinical Microbiology and Infection  Volume 8, Issue 1, Pages 31-37 (January 2002) DOI: 10.1046/j.1469-0691.2002.00375.x Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 Comparison of TNF-α, IL-6, IFN-γ and IL-10 levels in plasma and spleen and brain homogenates between male (open blocks) and female (shaded blocks) OF1 mice killed 6 days after inoculation with 2 × 106 C. neoformans/mouse. Results are expressed as means ± SEM (n = 5 in each group). ≥P = 0.009; †P<0.03 (Mann-Whitney). Clinical Microbiology and Infection 2002 8, 31-37DOI: (10.1046/j.1469-0691.2002.00375.x) Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Comparison of fungal burden in blood, spleen and brain (a) and TNF-α, IL-6, IFN-γ and IL-10 levels in plasma (b) and spleen homogenates (c) between young (open blocks) and old (shaded blocks) CD1 male mice killed 8 days after inoculation with 2 × 106 C. neoformans/mouse. Results are expressed as means ± SEM (n = 7 in each group). ≥P<0.02; †P<0.05 (Mann-Whitney). Clinical Microbiology and Infection 2002 8, 31-37DOI: (10.1046/j.1469-0691.2002.00375.x) Copyright © 2002 European Society of Clinical Infectious Diseases Terms and Conditions