Timeline, Epidemiology, and Risk Factors for Bacterial, Fungal, and Viral Infections in Children and Adolescents after Allogeneic Hematopoietic Stem Cell.

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Presentation transcript:

Timeline, Epidemiology, and Risk Factors for Bacterial, Fungal, and Viral Infections in Children and Adolescents after Allogeneic Hematopoietic Stem Cell Transplantation Ashok Srinivasan, Chong Wang, Deo K. Srivastava, Ken Burnette, Jerry L. Shenep, Wing Leung, Randall T. Hayden Biology of Blood and Marrow Transplantation Volume 19, Issue 1, Pages 94-101 (January 2013) DOI: 10.1016/j.bbmt.2012.08.012 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Percentage of patients with bacterial, fungal, and viral infections 0 to 30 days (A), 31 to 100 days (B), and 101 days to 2 years posttransplantation (C). A, There were 73 (10)/25 (3) patients with gram-positive (GP)/gram-negative (GN; P < .0001), 20 (3)/28 (4) patients with yeast/mold (M; P = .14), 12 (2)/19 (3) patients with candidemia (Cand)/proven aspergillus (Asperg; P = .21), 52 (7)/40 (5)/6 (1)/22 (3) patients with herpes simplex virus (HSV)/cytomegalovirus (CMV)/Epstein-Barr virus (EBV)/adenovirus (ADV; P < .0001), and 14 (2)/6 (1)/7 (1) patients with parainfluenza (PIV)/influenza (Infl)/respiratory syncytial virus (RSV; P = .49) infection of a total of 759 patients. B, There were 112 (16)/33 (4) patients with GP/GN (P < .0001), 18 (3)/28 (4) patients with yeast/mold (P = .12), 5 (<1)/11 (1) patients with Cand/Asperg (P = .13), 10 (1)/65 (9)/23 (3)/19 (3) patients with HSV/CMV/EBV/ADV (P < .0001), and 8 (1)/1 (0.1)/10 (1) patients with PIV/Infl/RSV (P = .03) infection of a total of 735 patients. C, There were 121 (19)/62 (10) patients with GP/GN (P < .0001), 39 (6)/43 (7) patients with yeast/mold (P = .57), 9 (1)/19 (3) patients with Cand/Asperg (P = .08); 14 (2)/14 (2)/7 (1)/20 (3) patients with HSV/CMV/EBV/ADV (P = .12), and 30 (5)/25 (4)/15 (2) patients with PIV/Infl/RSV (P = .10) infection of a total of 622 patients. Percentages are indicated in parenthesis. Yeast infections include those in blood and other sites. Mold infections include Aspergillus, non-Aspergillus molds, and probable invasive fungal infections. Biology of Blood and Marrow Transplantation 2013 19, 94-101DOI: (10.1016/j.bbmt.2012.08.012) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions