Volume 22, Issue 2, Pages 204-206 (February 1999) A Sweet Beginning  Catherine Dulac  Neuron  Volume 22, Issue 2, Pages 204-206 (February 1999) DOI: 10.1016/S0896-6273(00)81079-X

Figure 1 Schematic Organization of Taste Sensory Neurons The tongue epithelium displays regional preferences to sweet, bitter, sour, and salty compounds. TR2, the putative receptor for bitter tastants, is localized in the apical membrane of taste receptor cells, mostly, although not exclusively, in taste buds of circumvallate papillae in the back of the tongue that show preferential sensitivity to bitter. In contrast, TR1, the putative receptor for sweet, is mainly expressed in taste cells of fungiform papillae of the front of the tongue that show gustatory preference for sweet compounds. Neuron 1999 22, 204-206DOI: (10.1016/S0896-6273(00)81079-X)