Rodolfo Montironi, Ming Zhou, Cristina Magi-Galluzzi, Jonathan I

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Features and Prognostic Significance of Intraductal Carcinoma of the Prostate Rodolfo Montironi, Ming Zhou, Cristina Magi-Galluzzi, Jonathan I. Epstein European Urology Oncology Volume 1, Issue 1, Pages 21-28 (May 2018) DOI: 10.1016/j.euo.2018.03.013 Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 1 A wide range of morphological patterns may be seen in intraductal carcinoma. (A) Dense cribriform structures partly involving a gland with (B) a retained basal cell layer on immunostaining for high–molecular weight cytokeratin and P63. Note the invasive carcinoma in the vicinity. (C) Dense cribriform glands. (D) Solid glands showing two-cell populations with central small and uniform nuclei and peripheral more pleomorphic nuclei. (E) Glands with comedonecrosis. (F) Intraductal carcinoma partly involving benign glands. (G) Glands with cells with marked variation in nuclear size and shape that are six or more times greater than the adjacent nuclei. European Urology Oncology 2018 1, 21-28DOI: (10.1016/j.euo.2018.03.013) Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 2 (A) Atypical intraductal proliferation that is morphologically more atypical than high-grade prostatic intraepithelial neoplasia, with several large loose cribriform glands lined with uniform nuclei, but is insufficient for intraductal carcinoma. (B) Retained basal cell layer on immunostaining for high–molecular weight cytokeratin and P63. European Urology Oncology 2018 1, 21-28DOI: (10.1016/j.euo.2018.03.013) Copyright © 2018 European Association of Urology Terms and Conditions