Optimization of opioid therapy for preventing incident pain associated with bone metastases  Sebastiano Mercadante, MD, Patrizia Villari, MD, Patrizia Ferrera, MD, Alessandra Casuccio, BS  Journal of Pain and Symptom Management  Volume 28, Issue 5, Pages 505-510 (November 2004) DOI: 10.1016/j.jpainsymman.2004.02.024 Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Construct for opioid titration in incident pain. Journal of Pain and Symptom Management 2004 28, 505-510DOI: (10.1016/j.jpainsymman.2004.02.024) Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Example of pain intensity (at rest and with movement) at admission (a), one day after achieving basal pain control, less than 4/10 (b), after optimizing opioid doses (c). Journal of Pain and Symptom Management 2004 28, 505-510DOI: (10.1016/j.jpainsymman.2004.02.024) Copyright © 2004 U.S. Cancer Pain Relief Committee Terms and Conditions