Pigmentation after using topical tacrolimus to treat lichen sclerosus: Possible role of stem cell factor Young Jin Kim, MD, Hee Young Kang, MD, PhD

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Presentation transcript:

Pigmentation after using topical tacrolimus to treat lichen sclerosus: Possible role of stem cell factor Young Jin Kim, MD, Hee Young Kang, MD, PhD Journal of the American Academy of Dermatology Volume 57, Issue 5, Pages S125-S127 (November 2007) DOI: 10.1016/j.jaad.2006.02.047 Copyright © 2007 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Hypopigmented patch on right cheek. B, After 3 months of therapy, brownish pigmentation localized at site of tacrolimus application. Journal of the American Academy of Dermatology 2007 57, S125-S127DOI: (10.1016/j.jaad.2006.02.047) Copyright © 2007 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histopathologic and immunohistochemical findings of hyperpigmented skin after tacrolimus use were compared with previous hypopigmented and normal skin. (A-C, Hematoxylin-eosin stain; original magnification: ×100). Fontana-Masson stain (D-F), NKI/beteb detection of epidermal melanocytes (G-I), and reactions with antibodies to stem cell factor (J-L) and vimentin (M-O) are shown. (D-O, Original magnifications: ×200.) Journal of the American Academy of Dermatology 2007 57, S125-S127DOI: (10.1016/j.jaad.2006.02.047) Copyright © 2007 American Academy of Dermatology, Inc. Terms and Conditions