Investigation of the mechanism of alcohol-induced bronchial asthma

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Presentation transcript:

Investigation of the mechanism of alcohol-induced bronchial asthma Terufumi Shimoda, MDa, Shigeru Kohno, MDa, Atsuko Takao, MDa, Chizu Fujiwara, MDa, Hiroto Matsuse, MDa, Hiroyuki Sakai, MDa, Takashi Watanabe, MDa, Kohei Hara, MDa, Sadahiro Asai, MDb Journal of Allergy and Clinical Immunology Volume 97, Issue 1, Pages 74-84 (January 1996) DOI: 10.1016/S0091-6749(96)70285-3 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Peak percent change in FEV1 after ethanol challenge. Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Serial changes in FEV1 after ingestion of ethanol. Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Mean change in blood ethanol concentration after ingestion of ethanol. Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 Mean change in blood acetaldehyde concentration after ingestion of ethanol. Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Mean change in blood histamine concentration after ingestion of ethanol. Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 6 Leukocyte histamine release induced by ethanol (2, 10, 20, and 100 mmol/L). Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 7 Leukocyte histamine release induced by acetaldehyde (2, 10, 20, and 100 μmol/L). Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 8 IgE antibodies specific for acetaldehyde-HSA. O.D., Optical density. Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 9 Mean changes in FEV1 after ethanol challenge after pretreatment with or without cyproheptadine (A), DSCG(B), and atropine (C). Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 9 Mean changes in FEV1 after ethanol challenge after pretreatment with or without cyproheptadine (A), DSCG(B), and atropine (C). Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 9 Mean changes in FEV1 after ethanol challenge after pretreatment with or without cyproheptadine (A), DSCG(B), and atropine (C). Journal of Allergy and Clinical Immunology 1996 97, 74-84DOI: (10.1016/S0091-6749(96)70285-3) Copyright © 1996 Mosby, Inc. Terms and Conditions