Conditional mutagenesis restricts the Lbx1FS mutation to specific neuronal subpopulations. Conditional mutagenesis restricts the Lbx1FS mutation to specific.

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Conditional mutagenesis restricts the Lbx1FS mutation to specific neuronal subpopulations. Conditional mutagenesis restricts the Lbx1FS mutation to specific neuronal subpopulations. (A) Analysis of Lbx1+ (red) Phox2b+ (green) RTN neurons (arrowheads) in control, dB2-Lbx1FS and Egr2-Lbx1FS newborn mice. DAPI (blue) was used as a counterstain, and the facial (nVII) motor nucleus is indicated. Confocal tile scan modus was used to acquire photomicrographs, and assembled using ZEN2012 software (10% overlap between tiles). (B, Top) Comparison of dB2 neuron numbers: RTN neurons [one-way ANOVA, F(3, 15) = 883.4]; dorsal Lbx1+/Phox2b+ neurons [one-way ANOVA, F(3, 15) = 370] and periV neurons [one-way ANOVA, F(3, 15) = 0.1562] in control (n = 6) Lbx1FS/FS (n = 4), Egr2-Lbx1FS (n = 4), and dB2-Lbx1FS (n = 4) mice. (B, Bottom) Comparison of ventilatory minute volumes in normal air and in hypercapnia in control (n = 20) Lbx1FS/FS (n = 11), Egr2-Lbx1FS (n = 11), and dB2-Lbx1FS (n = 12) mice (unpaired nonparametric Mann–Whitney U test). Luis Rodrigo Hernandez-Miranda et al. PNAS doi:10.1073/pnas.1813520115 ©2018 by National Academy of Sciences