Long-term up-regulation of proliferative markers and down-regulation of cell migration factors along with increased intestinal metaplasia after 56Fe radiation.

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Long-term up-regulation of proliferative markers and down-regulation of cell migration factors along with increased intestinal metaplasia after 56Fe radiation. Long-term up-regulation of proliferative markers and down-regulation of cell migration factors along with increased intestinal metaplasia after 56Fe radiation. (A) Representative immunoblot images are presented showing increased β-catenin, EphB3, and β1-integin and decreased expression of E-cadherin, Par3, Zo-1, and Map1b 12 mo after 56Fe radiation. (B) E-cadherin expression was assessed by immunofluorescence in intestinal sections, and representative images are presented showing decreased expression after 56Fe radiation. (Scale bars, 10 μm.) (C) Representative immunofluorescence images of Par3 from intestinal sections are presented showing decreased expression after 56Fe radiation. (Scale bars, 10 μm.) (D) Expression of GC-C, a marker of intestinal metaplasia, is shown in representative images. (Scale bars, 10 μm.)‏ Santosh Kumar et al. PNAS 2018;115:42:E9832-E9841 ©2018 by National Academy of Sciences