Dry mouth: A critical topic for older adult patients Phuu Han, DDS, PhD, Piedad Suarez-Durall, DDS, Roseann Mulligan, DDS, MS  Journal of Prosthodontic Research  Volume 59, Issue 1, Pages 6-19 (January 2015) DOI: 10.1016/j.jpor.2014.11.001 Copyright © 2014 Japan Prosthodontic Society Terms and Conditions

Fig. 1 Schematic diagram of time of onset and duration of radiation-induced oral sequelae. Reprinted from Ref. [71] with permission from Elsevier. Journal of Prosthodontic Research 2015 59, 6-19DOI: (10.1016/j.jpor.2014.11.001) Copyright © 2014 Japan Prosthodontic Society Terms and Conditions

Fig. 2 Diagnosis and treatment of salivary gland hypofunction and xerostomia. Reprinted from Ref. [63] with permission from Springer. Journal of Prosthodontic Research 2015 59, 6-19DOI: (10.1016/j.jpor.2014.11.001) Copyright © 2014 Japan Prosthodontic Society Terms and Conditions

Fig. 3 Treatment gap analysis. Synthesis of the solutions for addressing xerostomia in H&N cancer patients undergoing RT. The solutions are summarized in a graph showing the effectiveness of the solution at treating or preventing xerostomia versus the cost per treatment. The solutions are categorized according to the following criteria: treatment versus prevention and preclinical versus clinical stage. Relative clinical availability is also estimated and represented as bubble size. Highlighted by the dashed circle is the treatment gap, which corresponds to the area of greatest innovation opportunity. Reprinted from Ref. [49] with permission from Elsevier. Journal of Prosthodontic Research 2015 59, 6-19DOI: (10.1016/j.jpor.2014.11.001) Copyright © 2014 Japan Prosthodontic Society Terms and Conditions