Balance of Power in Host-Virus Arms Races

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Presentation transcript:

Balance of Power in Host-Virus Arms Races Kin-Hang Kok, Dong-Yan Jin Cell Host & Microbe Volume 14, Issue 1, Pages 5-6 (July 2013) DOI: 10.1016/j.chom.2013.07.004 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Striking a Balance in Host-Ebola Virus Interaction Ebola virus VP35 is a dsRNA-binding protein and an essential cofactor of the viral polymerase complex, which also contains NP and L proteins. In this context, VP35 functions to facilitate viral RNA synthesis and replication. On the other hand, VP35 is an interferon-antagonizing protein that counteracts PACT and RIG-I to inhibit the activation of interferon production. Ebola virus suppression of PACT by VP35 comes at the cost of having VP35’s activity in viral replication inhibited by PACT. Cell Host & Microbe 2013 14, 5-6DOI: (10.1016/j.chom.2013.07.004) Copyright © 2013 Elsevier Inc. Terms and Conditions