Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin a- induced bronchoconstriction Nunzio Crimi, MD, Corrado Pagano, MD,

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Inhibitory effect of a leukotriene receptor antagonist (montelukast) on neurokinin a- induced bronchoconstriction Nunzio Crimi, MD, Corrado Pagano, MD, Filippo Palermo, BSc, Claudio Mastruzzo, MD, PhD, Gaetano Prosperini, MD, Maria P. Pistorio, BSc, Carlo Vancheri, MD, PhD Journal of Allergy and Clinical Immunology Volume 111, Issue 4, Pages 833-839 (April 2003) DOI: 10.1067/mai.2003.161 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Study design: a 2-phase, randomized, placebo-controlled, crossover study. In the first phase a concentration-response study was performed either with methacholine or NKA in the absence of any drug treatment. During the second phase, each subject recruited went through all possible combinations of drug administration and challenge procedures. R, Random; Meth, methacholine; M, montelukast; P, placebo. Journal of Allergy and Clinical Immunology 2003 111, 833-839DOI: (10.1067/mai.2003.161) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of montelukast (filled squares) compared with placebo (open triangles) on the concentration-response curves to inhaled NKA in 9 asthmatic subjects. Journal of Allergy and Clinical Immunology 2003 111, 833-839DOI: (10.1067/mai.2003.161) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Mean values of the area under the concentration-response curve to inhaled NKA after placebo and montelukast treatment. Journal of Allergy and Clinical Immunology 2003 111, 833-839DOI: (10.1067/mai.2003.161) Copyright © 2003 Mosby, Inc. Terms and Conditions