RAS unplugged: Negative feedback and oncogene-induced senescence

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RAS unplugged: Negative feedback and oncogene-induced senescence Nabeel Bardeesy, Norman E. Sharpless Cancer Cell Volume 10, Issue 6, Pages 451-453 (December 2006) DOI: 10.1016/j.ccr.2006.11.015 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Two models of oncogene-induced senescence A: Activated RAS leads to growth arrest as a result of potent negative feedback that abrogates ERK and PI3K signaling. The red lines indicate negative feedback signals. B: RAS activation induces DNA damage via the production of ROS, which has been suggested to induce senescence through a few disparate mechanisms. These models differ in biochemical emphasis but are not mutually exclusive. Cancer Cell 2006 10, 451-453DOI: (10.1016/j.ccr.2006.11.015) Copyright © 2006 Elsevier Inc. Terms and Conditions