Synaptic transmission: Spillover in the spotlight

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Synaptic transmission: Spillover in the spotlight Jeffry S Isaacson Current Biology Volume 10, Issue 13, Pages R475-R477 (June 2000) DOI: 10.1016/S0960-9822(00)00551-0

Figure 1 GABA and glutamate mediate fast inhibitory and excitatory transmission via synaptic GABAA and ionotropic AMPA/NMDA receptors (iGluRs), respectively. Recent studies reveal that spillover of synaptic GABA activates metabotropic GABAB receptors on dendrites and excitatory nerve endings. Conversely, synaptically-released glutamate diffuses to inhibitory nerve terminals where it inhibits GABA release via metabotropic glutamate receptors (mGluRs). Current Biology 2000 10, R475-R477DOI: (10.1016/S0960-9822(00)00551-0)