Volume 81, Issue 4, Pages (February 2012)

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Volume 81, Issue 4, Pages 401-406 (February 2012) A composite urine biomarker reflects interstitial inflammation in lupus nephritis kidney biopsies Xiaolan Zhang, Haikady N. Nagaraja, Tibor Nadasdy, Huijuan Song, Alison McKinley, Jason Prosek, Swapna Kamadana, Brad H. Rovin Kidney International Volume 81, Issue 4, Pages 401-406 (February 2012) DOI: 10.1038/ki.2011.354 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Receiver operating characteristic (ROC) curve for a composite biomarker of renal interstitial inflammation. This ROC curve is based on Equation (1) that combines urine monocyte chemoattractant protein-1 (uMCP-1) and serum creatinine (SCr) to differentiate biopsies with none–mild interstitial inflammation from moderate–severe interstitial inflammation. The area under the curve (AUC) is 0.92. Kidney International 2012 81, 401-406DOI: (10.1038/ki.2011.354) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 2 Receiver operating characteristic (ROC) curve for a composite biomarker of renal interstitial fibrosis. This ROC curve is based on Equation (2) that combines urine hepcidin (uHep) and urine protein/creatinine ratio (uPCR) to differentiate biopsies with none–mild interstitial fibrosis from moderate–severe interstitial fibrosis. The area under the curve (AUC) is 0.74. Kidney International 2012 81, 401-406DOI: (10.1038/ki.2011.354) Copyright © 2012 International Society of Nephrology Terms and Conditions