Relationship between hepatocellular injury and transfusional iron overload prior to and during iron chelation with desferrioxamine: a study in adult patients with acquired anemias by Peter D. Jensen, Finn T. Jensen, Thorkil Christensen, Johan L. Nielsen, and Joergen Ellegaard Blood Volume 101(1):91-96 January 1, 2003 ©2003 by American Society of Hematology

Relationship between aminotransferase serum levels and several indices of iron status in 39 nonthalassemic adult patients with transfusional iron overload.Horizontal lines represent upper reference limit for ALT (40 U/L) and ALT (40 U/L) serum activity. Relationship between aminotransferase serum levels and several indices of iron status in 39 nonthalassemic adult patients with transfusional iron overload.Horizontal lines represent upper reference limit for ALT (40 U/L) and ALT (40 U/L) serum activity. The serum ferritin panels also show regression of ALT and AST to the serum ferritin concentration. For further details, see “Patients, materials, and methods.” Peter D. Jensen et al. Blood 2003;101:91-96 ©2003 by American Society of Hematology

Follow-up data on the ALT and indices of iron status in 12 patients with transfusional iron overload on iron chelation with DFO.Individual patients may be identified within the different panels by use of a single symbol and color for each patient. Follow-up data on the ALT and indices of iron status in 12 patients with transfusional iron overload on iron chelation with DFO.Individual patients may be identified within the different panels by use of a single symbol and color for each patient. Urinary iron excretion was not measured in patients 3 and 12. The horizontal line in panel A represent the upper reference limit for ALT serum activity (40 U/L). Peter D. Jensen et al. Blood 2003;101:91-96 ©2003 by American Society of Hematology

Relationship between ALT and AST and liver iron concentration during iron chelation by lowess regression (tension = 66).Data are obtained from Figure 2, panels A and C, and corresponding AST values (not shown in Figure 2). Relationship between ALT and AST and liver iron concentration during iron chelation by lowess regression (tension = 66).Data are obtained from Figure 2, panels A and C, and corresponding AST values (not shown in Figure 2). The total number of observations is 86 in panel A and 83 in panel B. Horizontal lines represent upper reference limits for ALT and AST (40 U/L). Peter D. Jensen et al. Blood 2003;101:91-96 ©2003 by American Society of Hematology

Relationships between the ALT and indices of iron status and interrelationships during iron chelation by lowess regression (tension = 66).The data are obtained from Figure 2, panels A to D. The total number of observations is 66 in panel A, 68 in panel B, a... Relationships between the ALT and indices of iron status and interrelationships during iron chelation by lowess regression (tension = 66).The data are obtained from Figure 2, panels A to D. The total number of observations is 66 in panel A, 68 in panel B, and 86 in panels C and D. Lines in panels A-B show regression of ALT to the urinary iron excretion and the serum ferritin concentration; lines in panels C-D show regression of urinary iron excretion and serum ferritin concentration to the liver iron concentration. Peter D. Jensen et al. Blood 2003;101:91-96 ©2003 by American Society of Hematology