Volume 142, Issue 5, Pages e3 (May 2012)

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Volume 142, Issue 5, Pages 1140-1149.e3 (May 2012) High Levels of Hepatitis B Surface Antigen Increase Risk of Hepatocellular Carcinoma in Patients With Low HBV Load Tai–Chung Tseng, Chun–Jen Liu, Hung–Chih Yang, Tung–Hung Su, Chia–Chi Wang, Chi–Ling Chen, Stephanie Fang–Tzu Kuo, Chen– Hua Liu, Pei–Jer Chen, Ding–Shinn Chen, Jia–Horng Kao Gastroenterology Volume 142, Issue 5, Pages 1140-1149.e3 (May 2012) DOI: 10.1053/j.gastro.2012.02.007 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Flow of study participants. Gastroenterology 2012 142, 1140-1149.e3DOI: (10.1053/j.gastro.2012.02.007) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 Cumulative incidence of HCC in a cohort of 2688 HBsAg-positive patients was associated with (A) serum HBeAg status, (B) ALT level, (C) HBV DNA level, and (D) HBsAg level at study entry. A better prediction of serum HBV and ALT levels than HBsAg level for HCC within (E) 10 years of follow-up (n = 2491) and (F) 15 years of follow-up (n = 1219) by ROC curve analysis. Gastroenterology 2012 142, 1140-1149.e3DOI: (10.1053/j.gastro.2012.02.007) Copyright © 2012 AGA Institute Terms and Conditions

Figure 3 In 1068 HBeAg-negative patients with HBV DNA level <2000 IU/mL. (A) HR of HCC in relation to HBsAg levels was analyzed using the restricted cubic spline regression with 3 knots on the 25th, 50th, and 75th percentiles. Cumulative incidence of HCC was analyzed by cutoff HBsAg levels of (B) 10 IU/mL, (C) 100 IU/mL, and (D) 1000 IU/mL in HBeAg-negative patients with HBV DNA level <2000 IU/mL and (E) by HBsAg level of 1000 IU/mL in HBeAg-negative patients with HBV DNA levels ≥2000 IU/mL. Gastroenterology 2012 142, 1140-1149.e3DOI: (10.1053/j.gastro.2012.02.007) Copyright © 2012 AGA Institute Terms and Conditions

Supplementary Figure 1 Positive relationships between serum levels of HBV DNA and HBsAg in patients with HBV DNA levels (A) ≥2000 IU/mL (r2 = 0.44, P < .001) and (B) <2000 IU/mL (r2 = 0.07, P < .001). Gastroenterology 2012 142, 1140-1149.e3DOI: (10.1053/j.gastro.2012.02.007) Copyright © 2012 AGA Institute Terms and Conditions

Supplementary Figure 2 Estimated curves of hazard ratio of HCC and corresponding Akaike information criterion (AIC) values in HBeAg-negative patients with HBV DNA level <2000 IU/mL by different regression models. Gastroenterology 2012 142, 1140-1149.e3DOI: (10.1053/j.gastro.2012.02.007) Copyright © 2012 AGA Institute Terms and Conditions