Hungry for Mechanism in Hippo Signaling

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Presentation transcript:

Hungry for Mechanism in Hippo Signaling Cell Volume 151, Issue 6, (December 2012) DOI: 10.1016/j.cell.2012.11.029 Copyright © 2012 Terms and Conditions

Ras activation and mitochondrial dysfunction (green) stimulate cell proliferation (magenta) of surrounding cells (blue). Image courtesy of Tatsushi Igaki. Cell 2012 151, DOI: (10.1016/j.cell.2012.11.029) Copyright © 2012 Terms and Conditions

Loss of LIFR causes lung metastasis of breast cancer cells, which can be reversed by depletion of YAP. Photos courtesy of Li Ma. Cell 2012 151, DOI: (10.1016/j.cell.2012.11.029) Copyright © 2012 Terms and Conditions

Mo et al. suggest a role for a GPCR (rainbow) in regulating Hippo signaling. Cell 2012 151, DOI: (10.1016/j.cell.2012.11.029) Copyright © 2012 Terms and Conditions

Hipk expression (red) promotes Yki activity (white) in the Drosophila melanogaster wing imaginal disc. Images courtesy of Carole Poon and Kieran Harvey. Cell 2012 151, DOI: (10.1016/j.cell.2012.11.029) Copyright © 2012 Terms and Conditions