Corticotropin- and Thyrotropin-Secreting Pituitary Microadenomas: Detection by Dynamic Magnetic Resonance Imaging  Robert C. Smallridge, MD, Leo F. Czervionke,

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Presentation transcript:

Corticotropin- and Thyrotropin-Secreting Pituitary Microadenomas: Detection by Dynamic Magnetic Resonance Imaging  Robert C. Smallridge, MD, Leo F. Czervionke, MD, Douglas W. Fellows, MC, USA, Maj Victor J. Bernet, MC, USA  Mayo Clinic Proceedings  Volume 75, Issue 5, Pages 521-528 (May 2000) DOI: 10.4065/75.5.521 Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 (case 1). Magnetic resonance images. Right pituitary adenoma is not evident on conventional coronal T,-weighted spin echo unenhanced (A) or gadolinium-enhanced (B) image. Pituitary gland (arrows). B was obtained after contrast equilibration, 10 minutes after A was obtained. Mayo Clinic Proceedings 2000 75, 521-528DOI: (10.4065/75.5.521) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 (case 1). Dynamic gadolinium-enhanced pituitary magnetic resonance images. Right pituitary microadenoma is visualized as an ovoid area of low intensity because of less enhancement of pituitary adenoma (arrows) (A, B, and C) relative to normal intense enhancement of pituitary gland. A obtained immediately, B obtained 40 seconds, and C obtained 160 seconds after injection of gadolinium containing paramagnetic contrast agent. Mayo Clinic Proceedings 2000 75, 521-528DOI: (10.4065/75.5.521) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 (case 2). Magnetic resonance images. There is no convincing evidence for a pituitary adenoma on conventional coronal T1-weighted spin echo unenhanced (A) or gadolinium-enhanced (B) image. There may be a very subtle decrease in signal intensity in the left side of the pituitary gland on the contrast-enhanced image (B). Pituitary gland (arrows) (A and B). Mayo Clinic Proceedings 2000 75, 521-528DOI: (10.4065/75.5.521) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 4 (case 2). Somatostatin receptor scintigraphy (OctreoScan) demonstrating a focal area of intense activity in the pituitary gland. Mayo Clinic Proceedings 2000 75, 521-528DOI: (10.4065/75.5.521) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 5 (case 2). Dynamic pituitary series of coronal gadolinium-enhanced magnetic resonance images showing left-sided microadenoma as a region of low signal intensity (arrows). A was obtained immediately after injection. B through F were obtained at 40, 80, 120, 160, and 200 seconds after injection, respectively. The microadenoma is most conspicuous on F. Mayo Clinic Proceedings 2000 75, 521-528DOI: (10.4065/75.5.521) Copyright © 2000 Mayo Foundation for Medical Education and Research Terms and Conditions