Clinical and Translational Radiation Oncology

Slides:

Advertisements

Similar presentations

Cardiac events after treatment with high dose radiation therapy +/- chemotherapy for non-small cell lung cancer Linglong Tang, Anwen Liu, Daniel Gomez,

Advertisements

Tumor Location Correlates with Radiation Pneumonitis after Stereotactic Body Radiation Therapy (SBRT) for Primary and Oligometastatic Lesions of the Lung.

Correlation of 18F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer Nadya Shusharina, PhD,

A Prognostic Scoring Model for the Utility of Induction Chemotherapy Prior to Neoadjuvant Chemoradiotherapy in Esophageal Cancer Mian Xi, MD, Zhongxing.

Volume 17, Issue 12, Pages (December 2016)

18Fluorodeoxyglucose PET Is Prognostic of Progression-Free and Overall Survival in Locally Advanced Pancreas Cancer Treated With Stereotactic Radiotherapy

Interstitial Lung Disease Following Single-Agent Nanoparticle Albumin-Bound Paclitaxel Treatment in Patients with Advanced Non-Small Cell Lung Cancer -

Hiromasa Nakayasu, Toshihiro Shirai, Yuko Tanaka, Mika Saigusa

Jeffrey Bradley, MD Journal of Thoracic Oncology

Fig. 1. Abnormalities on chest imaging of the patient

Image–Guided Radiation Therapy for Non–small Cell Lung Cancer

Effect of variations in atelectasis on tumor displacement during radiation therapy for locally advanced lung cancer Nathan Tennyson, MD, Elisabeth Weiss,

Preoperative Chemo-Radiation-Induced Ulceration in Patients with Esophageal Cancer: A Confounding Factor in Tumor Response Assessment in Integrated Computed.

Clinical Value of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in Differentiation of Malignant Mesothelioma from Asbestos-Related.

Sequential Immunologic Reactions after Suspension of Nivolumab Treatment in Lung Adenocarcinoma Patient Hiromichi Shirasu, MD, Akira Ono, MD, Toshiaki.

Correlation between urinary dose and delayed radiation cystitis after 78Gy intensity- modulated radiotherapy for high-risk prostate cancer: A 10-year follow-up.

Uptake of Prostate-Specific Membrane Antigen (PSMA) in adenoid cystic carcinoma – Is PSMA-PET-CT a helpful tool in radiation oncology? Laila König, Henrik.

Successful Osimertinib Rechallenge in a Patient with T790M-Mutant Non–Small Cell Lung Cancer after Osimertinib-Induced Interstitial Lung Disease Eisaku.

Prospective Study of Patient-Reported Symptom Burden in Patients With Non–Small- Cell Lung Cancer Undergoing Proton or Photon Chemoradiation Therapy Xin.

Jennifer C. Ho, MD, Quynh-Nhu Nguyen, MD, Heng Li, PhD, Pamela K

Improved outcome of treating locally advanced lung cancer with the use of Lattice Radiotherapy (LRT): A case report Beatriz E. Amendola, Naipy C. Perez,

Clinical and Translational Radiation Oncology

Michael C. Roach, MD, Gregory M. M. Videtic, MD, CM, FRCPC, Jeffrey D

Clinical and Translational Radiation Oncology

Waleed Brinjikji, MD, Jennifer M. Boland Froemming, MD, William P

Andreas Rimner, MD, Daniel R. Gomez, MD, Abraham J

Image–Guided Radiation Therapy for Non–small Cell Lung Cancer

Pulmonary Infiltrates and Eosinophilia Associated With Sulfasalazine

Heart Dose Is an Independent Dosimetric Predictor of Overall Survival in Locally Advanced Non–Small Cell Lung Cancer Christina K. Speirs, MD, PhD, Todd.

Long-Term Outcomes of Salvage Stereotactic Ablative Radiotherapy for Isolated Lung Recurrence of Non–Small Cell Lung Cancer: A Phase II Clinical Trial

Resection of Mucinous Lung Adenocarcinoma Presenting with Intractable Bronchorrhea Motoshi Takao, MD, PhD, Takehiro Takagi, MD, Hitoshi Suzuki, MD, PhD,

Influence of Preoperative Radiation Field on Postoperative Leak Rates in Esophageal Cancer Patients after Trimodality Therapy Aditya Juloori, BS, Susan.

Characterization of Pneumonitis in Patients with Advanced Non-small Cell Lung Cancer Treated with Everolimus (RAD001) Dorothy A. White, MD, Lawrence.

Uptake of Prostate-Specific Membrane Antigen (PSMA) in adenoid cystic carcinoma – Is PSMA-PET-CT a helpful tool in radiation oncology? Laila König, Henrik.

Esophageal Cancer Located at the Neck and Upper Thorax Treated with Concurrent Chemoradiation: A Single-Institution Experience Shulian Wang, MD, Zhongxing.

Radiological Changes After Stereotactic Radiotherapy for Stage I Lung Cancer Max Dahele, MBChB, MSc, David Palma, MD, Frank Lagerwaard, MD, PhD, Ben Slotman,

Local Control and Toxicity of a Simultaneous Integrated Boost for Dose Escalation in Locally Advanced Esophageal Cancer: Interim Results from a Prospective.

Clinical and Translational Radiation Oncology

Metabolic response by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). a) FDG PET/CT for patient 2 at baseline.

Successful immunotherapy and irradiation in a HIV-positive patient with metastatic Merkel cell carcinoma Annett Linge, Ricarda Rauschenberg, Sophia Blum,

Kiran Devisetty, MD, Joseph K. Salama, MD Journal of Thoracic Oncology

Preliminary Report of Late Recurrences, at 5 Years or More, after Stereotactic Body Radiation Therapy for Non-small Cell Lung Cancer Yukinori Matsuo,

Gross tumour delineation on computed tomography and positron emission tomography- computed tomography in oesophageal cancer: A nationwide study M.E. Nowee,

Patterns of Cardiac Perfusion Abnormalities After Chemoradiotherapy in Patients with Lung Cancer Isis W. Gayed, MD, H Helen Liu, PhD, Xiong Wei, MD,

Follow up results of a prospective study to evaluate the impact of FDG-PET on CT- based radiotherapy treatment planning for oesophageal cancer Sweet Ping.

Evaluating the prevalence and predictive factors of vasomotor and psychological symptoms in prostate cancer patients receiving hormonal therapy: Results.

Emma Hudson, MRCP, Jason F. Lester, FRCR

The role of positron emission tomography for non-small cell lung cancer Albert J. Chang, MD, PhD, Farrokh Dehdashti, MD, Jeffrey D. Bradley, MD Practical.

Daniel Morgensztern, MD, Boone Goodgame, MD, Maria Q

Re-evaluating the Optimal Radiation Dose for Definitive Chemoradiotherapy for Esophageal Squamous Cell Carcinoma Liru He, MD, Pamela K. Allen, PhD, Adam.

Stereotactic Ablative Radiation Therapy for Lung Oligometastases: Predictive Parameters of Early Response by 18FDG-PET/CT Rosario Mazzola, MD, Alba Fiorentino,

PD5-2-5: Local therapy of primary diseae improves survival in non-small cell lung cancer metastatic to a single organ - a lesson from brain metastases

A Patient With BRAF V600E Lung Adenocarcinoma Responding to Vemurafenib Oliver Gautschi, MD, Chantal Pauli, MD, Klaus Strobel, MD, Astrid Hirschmann,

Positron Emission Tomography 18F-Fluorodeoxyglucose Uptake and Prognosis in Patients with Surgically Treated, Stage I Non-small Cell Lung Cancer: A Systematic.

Patterns of Failure, Toxicity, and Survival after Extrapleural Pneumonectomy and Hemithoracic Intensity-Modulated Radiation Therapy for Malignant Pleural.

Value of Combined Interpretation of Computed Tomography Response and Positron Emission Tomography Response for Prediction of Prognosis After Neoadjuvant.

Jennifer L. Dallas, MD, Michael A. Jantz, MD, Judith L

Osteoblastic Bone Flare on F18-FDG PET in Non-small Cell Lung Cancer (NSCLC) Patients Receiving Bevacizumab in Addition to Standard Chemotherapy Yelena.

Histological Subtypes of Lung Adenocarcinoma Have Differential 18F- Fluorodeoxyglucose Uptakes on the Positron Emission Tomography/Computed Tomography.

Jeffrey Bradley, MD Journal of Thoracic Oncology

A Prognostic Scoring Model for the Utility of Induction Chemotherapy Prior to Neoadjuvant Chemoradiotherapy in Esophageal Cancer Mian Xi, MD, Zhongxing.

Association between Systemic Chemotherapy before Chemoradiation and Increased Risk of Treatment-Related Pneumonitis in Esophageal Cancer Patients Treated.

Primary Tumor Standardized Uptake Value Measured on F18-Fluorodeoxyglucose Positron Emission Tomography Is of Prediction Value for Survival and Local.

Correlation between FMISO-PET based hypoxia in the primary tumour and in lymph node metastases in locally advanced HNSCC patients Anna Bandurska-Luque,

Todd J. Carpenter, MD, Kenneth E. Rosenzweig, MD

PD6-1-6: Mid-course resimulation for small cell lung cancer patients receiving definitive chemoradiation: sparing of normal lung and esophagus without.

Prognostic Role of Positron Emission Tomography and High-Resolution Computed Tomography in Clinical Stage IA Lung Adenocarcinoma Hirofumi Uehara, MD,

Lack of FDG Uptake in Small Cell Carcinoma Associated with ANNA-1 Positive Paraneoplastic Autonomic Neuropathy Matthew S. Block, MD, PhD, Robert Vassallo,

A Review of First-Line Treatment for Small-cell Lung Cancer

Dose-Escalated Stereotactic Body Radiotherapy (SBRT) as a Salvage Treatment for Two Cases with Relapsed Peripheral Lung Cancer After Initial SBRT Shuichi.

Presentation transcript:

Clinical and Translational Radiation Oncology Association of lung fluorodeoxyglucose uptake with radiation pneumonitis after concurrent chemoradiation for non-small cell lung cancer Jinbo Yue, Matthew McKeever, Terence T. Sio, Ting Xu, Jinhai Huo, Qiuling Shi, Quynh-Nhu Nguyen, Ritsuko Komaki, Daniel R. Gomez, Tinsu Pan, Xin Shelley Wang, Zhongxing Liao Clinical and Translational Radiation Oncology Volume 4, Pages 1-7 (June 2017) DOI: 10.1016/j.ctro.2017.04.001 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 PET/CT fusion scans from a patient showing inflammatory infiltration of the lungs, with interstitial infiltrates, ground glass opacities, homogeneous consolidation, and patchy consolidation. (A) Scan obtained before treatment; the bright yellow area inside the white outline is the primary lung tumor. (B) Scan obtained 2months after treatment; the bright yellow area inside the white outline represents interstitial infiltrates. Scans obtained at 4months (C), 7months (D), and 10months after treatment (E) illustrate the course of interstitial infiltration over time. Clinical and Translational Radiation Oncology 2017 4, 1-7DOI: (10.1016/j.ctro.2017.04.001) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Longitudinal correlations between SUV variables and radiation pneumonitis (RP). All four variables studied [(A) SUVmax, (B) SUVpeak, (C) SUVmean, and (D) global lung glycolysis {GLG}] showed significant correlations with RP of grade 0–1 and 2–3 during the first 6months after therapy, but not thereafter. All four of these variables were higher in patients with CTCAE RP grade≥2 than in patients with CTCAE RP 0–1 during the first 6months after treatment, but not thereafter. Abbreviations: SUV, standardized uptake value; GLG, global lung glycolysis; CTCAE, Common Terminology Criteria for Adverse Events version 3; post 1, 1–3months after treatment; post 2, 4–6months after treatment; post 3, 7–9months after treatment; post 4, 10–12months after treatment. Clinical and Translational Radiation Oncology 2017 4, 1-7DOI: (10.1016/j.ctro.2017.04.001) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Cumulative probabilities of developing grade 0, 1, 2, or 3 radiation pneumonitis (RP) according to FDG uptake variables on PET. Panels A and B, SUVmean; panels C and D, SUVmax; panels E and F, SUVpeak; panels G and H, global lung glycolysis. Abbreviations: SUV, standardized uptake value; post1, 1–3months after treatment; post2, 4–6months after treatment. Clinical and Translational Radiation Oncology 2017 4, 1-7DOI: (10.1016/j.ctro.2017.04.001) Copyright © 2017 The Authors Terms and Conditions