Estrogen effects on triglyceride metabolism in analbuminemic rats

Slides:

Advertisements

Similar presentations

Reduced renal function in patients with simple renal cysts

Advertisements

Volume 54, Issue 4, Pages (October 1998)

Volume 65, Issue 6, Pages (June 2004)

E. Cavalier, P. Delanaye, A. Carlisi, J. -M. Krzesinski, J. -P

Plasma sodium and hypertension

Dyslipidemia in chronic kidney disease: Causes and consequences

Lipopheresis in the nephrotic syndrome

Nephrotic livers secrete normal VLDL that acquire structural and functional defects following interaction with HDL Gregory C. Shearer, William G. Couser,

Volume 67, Issue 2, Pages (February 2005)

Glomerulus number and blood pressure in the Prague hypertensive rat

Volume 57, Issue 5, Pages (May 2000)

Volume 59, Issue 1, Pages (January 2001)

Volume 58, Issue 1, Pages (July 2000)

Effects of antihypertensive therapy on intrarenal angiotensin and bradykinin levels in experimental renal insufficiency Fiona E. Mackie, Timothy W. Meyer,

George A. Kaysen, Burl R. Don

Abnormalities in lipoprotein metabolism in hemodialysis patients

Estrogen induces glomerulosclerosis in analbuminemic rats

Volume 7, Issue 2, Pages (February 2008)

Volume 82, Issue 9, Pages (November 2012)

Volume 56, Issue 5, Pages (November 1999)

Proinflammatory effects of iron sucrose in chronic kidney disease

Volume 65, Issue 5, Pages (May 2004)

Kamila Czene, Ph.D., Kari Hemminki Kidney International

Volume 61, Issue 1, Pages (January 2002)

Nephrotic livers secrete normal VLDL that acquire structural and functional defects following interaction with HDL Gregory C. Shearer, William G. Couser,

Volume 55, Issue 3, Pages (March 1999)

Volume 86, Issue 2, Pages (August 2014)

Volume 87, Issue 2, Pages (February 2015)

Gentamicin pharmacokinetics during slow daily home hemodialysis

New insights into lipid metabolism in the nephrotic syndrome

Volume 62, Issue 4, Pages (October 2002)

Volume 61, Issue 6, Pages (June 2002)

Volume 65, Issue 6, Pages (June 2004)

20-HETE in acute kidney injury

Volume 70, Issue 4, Pages (August 2006)

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Volume 87, Issue 1, Pages (January 2015)

Choong Kim, Nosratola D. Vaziri Kidney International

Volume 67, Issue 4, Pages (April 2005)

Volume 53, Issue 4, Pages (April 1998)

Reduced renal function in patients with simple renal cysts

Nephrology Crossword: Glomerulonephritis

Cameron Mcleod, Alan Cox, Neil Bramall Kidney International

Lipoprotein-stimulated mesangial cell proliferation and gene expression are regulated by lipoprotein lipase1 Frazier T. Stevenson, Gregory C. Shearer,

Neurogenic factors and hypertension in renal disease

Volume 56, Pages S235-S237 (July 1999)

H+-ATPase activity on unilateral ureteral obstruction: Interaction of endogenous nitric oxide and angiotensin II Patricia G. Valles, Walter A. Manucha

Volume 56, Pages S213-S215 (July 1999)

Volume 54, Issue 4, Pages (October 1998)

Mediterranean diets: are they practical in the Western world?

Volume 57, Issue 5, Pages (May 2000)

Volume 55, Issue 3, Pages (March 1999)

Silvia B. Campos, Lucia H.K. Rouch, Antonio C. Seguro

Organ transplantation goes to the movies

David Z. Levine, M.D., Michelle Iacovitti, Kevin D. Burns, Amy Slater

Molecular mechanisms of altered cholesterol metabolism in rats with spontaneous focal glomerulosclerosis Nosratola D. Vaziri, Tadashi Sato, Kaihui Liang

Volume 65, Issue 4, Pages (April 2004)

Volume 60, Issue 6, Pages (December 2001)

Does fluvastatin really have an antioxidant effect in humans?

Volume 59, Issue 1, Pages (January 2001)

Volume 70, Issue 5, Pages (September 2006)

Volume 62, Issue 5, (November 2002)

Volume 81, Issue 11, Pages (June 2012)

Volume 61, Issue 1, Pages (January 2002)

Volume 55, Issue 3, Pages (March 1999)

Rebound kinetics of β2-microglobulin after hemodialysis

Volume 57, Issue 4, Pages (April 2000)

Volume 61, Issue 4, Pages (April 2002)

Lipoprotein abnormalities in diabetic nephropathy

Presentation transcript:

Estrogen effects on triglyceride metabolism in analbuminemic rats Gregory C. Shearer, Jaap A. Joles, Hardin Jones, Rosemary L. Walzem, George A. Kaysen Kidney International Volume 57, Issue 6, Pages 2268-2274 (June 2000) DOI: 10.1046/j.1523-1755.2000.00087.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Plasma triglyceride levels in male, female, and ovariectomized (OVX) Sprague-Dawley (SD) rats and Nagase analbuminemic rats (NAR). Mean plasma triglycerides levels were measured from tail blood of rats fasted for 16 hours. Intact females (Fem), OVX females, and males are represented from each breed. Error bars represent SEM. †P < 0.05 vs. female SD; ‡P < 0.05 vs. female NAR, female SD; P < 0.05 vs. female NAR, OVX NAR, female SD. Kidney International 2000 57, 2268-2274DOI: (10.1046/j.1523-1755.2000.00087.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Plasma very-low density lipoprotein (VLDL) secretion rates in male, female, and ovariectomized SD rats and NAR. The mean VLDL TG secretion rates were measured from TG concentration in serum from tail blood of fasted rats following an injection of 600 mg/kg Triton WR 1339. Intact females (Fem), ovariectomized females (OVX), and males are represented from each breed. Error bars represent SEM. †P < 0.05 vs. female SD; ‡P < 0.05 vs. female NAR. Kidney International 2000 57, 2268-2274DOI: (10.1046/j.1523-1755.2000.00087.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Postheparin lipase activity. Plasma lipase activity at five minutes following injection of 50 U heparin/kg. (A) Lipase activity inhibited by 1 mol/L NaCl. (B) Lipase activity not inhibited by 1 mol/L NaCl. Intact females, ovariectomized females (OVX), and males are represented from each breed. Error bars represent SEM. †P < 0.001 vs. all SD; ‡P < 0.05 vs. female SD; *P < 0.05 vs. female, OVX SD; **P < 0.05 vs. SD male. Kidney International 2000 57, 2268-2274DOI: (10.1046/j.1523-1755.2000.00087.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 4 Chylomicron triglyceride (TG) catabolism. Disappearance of label from rat blood after tail vein injection of labeled chylomicrons as measured by log10 (counts remaining). The t1/2 is in minutes. Error bars represent SEM for each time point. †P < 0.001 vs. all SD; §P < 0.05 vs. female and OVX SD; ‡P < 0.05 vs. female and male NAR. Kidney International 2000 57, 2268-2274DOI: (10.1046/j.1523-1755.2000.00087.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 5 Chylomicron cholesterol catabolism. Disappearance of glycerol [9,10-3H] trioleate from rat blood after tail vein injection of labeled chylomicrons as measured by log10 (counts remaining). The t1/2 is in minutes. Error bars represent SEM for each time point. †P < 0.001 vs. all SD; §P < 0.05 vs. female and OVX SD. Kidney International 2000 57, 2268-2274DOI: (10.1046/j.1523-1755.2000.00087.x) Copyright © 2000 International Society of Nephrology Terms and Conditions