T cell receptor Vβ (TCR-Vβ) expression in a drug-specific T cell line (TCL) and specificity assay of a TCL of patient P1. T cell receptor Vβ (TCR-Vβ) expression.

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T cell receptor Vβ (TCR-Vβ) expression in a drug-specific T cell line (TCL) and specificity assay of a TCL of patient P1. T cell receptor Vβ (TCR-Vβ) expression in a drug-specific T cell line (TCL) and specificity assay of a TCL of patient P1. (A) FACS staining of peripheral blood mononuclear cells was performed at day 0 and 10 d after specific stimulation with flucloxacillin. (B) The TCR-Vβ expression showed an oligoclonal outgrowth of TCR-Vβ9 and TCR-Vβ21.3. A specificity assay of a TCL that was generated from patient P1 was performed with flucloxacillin as antigen. The TCL showed a drug-specific and dose-dependent proliferation in the presence of flucloxacillin. Zoi Spanou et al. JASN 2006;17:2919-2927 ©2006 by American Society of Nephrology