Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study Guillaume Joguet, MD, Jean-Michel.

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Effect of acute Zika virus infection on sperm and virus clearance in body fluids: a prospective observational study Guillaume Joguet, MD, Jean-Michel Mansuy, PhD, Giulia Matusali, PhD, Safouane Hamdi, PhD, Marie Walschaerts, PhD, Lynda Pavili, PharmD, Stefanie Guyomard, PhD, Nadia Prisant, MD, Pierre Lamarre, MD, Nathalie Dejucq-Rainsford, PhD, Prof Christophe Pasquier, PhD, Prof Louis Bujan, PhD The Lancet Infectious Diseases Volume 17, Issue 11, Pages 1200-1208 (November 2017) DOI: 10.1016/S1473-3099(17)30444-9 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Frequency of Zika virus RNA detection in the different fluids according to timepoints after Zika virus infection symptoms onset in 15 patients The Lancet Infectious Diseases 2017 17, 1200-1208DOI: (10.1016/S1473-3099(17)30444-9) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 2 Zika virus viral load (Zika virus RNA Log copies per mL) in the fluids studied for all 15 patients According to the seminal viral load, three patterns were identified: (A) non-shedding patients (patients 1, 7, 12, 14); (B) seminal shedders with concomitant blood, urines shedding, or both (patients 2, 3, 4, 8, 9, 10); (C) long-term seminal shedding patients discordant with urine or blood shedding (patients 5, 6, 11, 13, 15). The dotted line represents the detection limit of the kit (2·48 log copies per mL). The Lancet Infectious Diseases 2017 17, 1200-1208DOI: (10.1016/S1473-3099(17)30444-9) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 3 Semen characteristics of the 15 Zika virus-infected patients according to timepoints after infection symptom onset (A) Total sperm count (millions per ejaculate). (B) Total motile sperm count (millions per ejaculate). (C) Normal sperm (%). (D) Multiple anomalies index. Data are median (IQR). *p<0·083 between day 7 and days 11, 20, 30, 60, 90, or 120. The Lancet Infectious Diseases 2017 17, 1200-1208DOI: (10.1016/S1473-3099(17)30444-9) Copyright © 2017 Elsevier Ltd Terms and Conditions