Type I Interferons Interfere with Liver Glucose Metabolism

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Type I Interferons Interfere with Liver Glucose Metabolism Güneş Parlakgul, Gökhan S. Hotamisligil Cell Metabolism Volume 25, Issue 6, Pages 1211-1212 (June 2017) DOI: 10.1016/j.cmet.2017.05.009 Copyright © 2017 Terms and Conditions

Figure 1 Type I IFN Signaling Drives Intrahepatic CD8+ T Cell Activation and Further Metabolic Deterioration in Obesity Chronic high-fat diet (HFD) induces CD8+ T cell expansion and activation, resulting in an increased CD8+/CD4+ ratio in liver, through type I interferon signaling. Ghazarian et al. propose an intestinal dysbiosis-liver-intrahepatic CD8+ T cell axis, which contributes to metaflammatory signaling and further disruption of insulin action in liver and impaired glucose metabolism. Cell Metabolism 2017 25, 1211-1212DOI: (10.1016/j.cmet.2017.05.009) Copyright © 2017 Terms and Conditions