White adipose tissue (HFD)

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Presentation transcript:

White adipose tissue (HFD) High-fat diet (HFD) Standard diet (SD) AHR activation Serum/plasma (HFD) Whole body Insulin ↔ Leptin ↔ Adiponectin ↔ FGF21 ↔ Glucose ↔ FFA ↔ Body weight gain ↔ Feed intake ↔ Glucose tolerance ↓ Insulin sensitivity ↔ (HFD) Insulin sensitivity ↓ (SD) Liver SOCS3 ↓ (HFD) Relative weight ↔ Triglyceride content ↑ (HFD) Cholesterol content ↔ Lipogenesis ↑ Fatty acid uptake ↔ (HFD) β-oxidation ↔ (HFD) Gluconeogenesis ↔ (HFD) Inflammation ↑ (HFD) Oxidative stress ↑ (HFD) Cholesterol biosynthesis ↑ (SD) Skeletal muscle (HFD) Triglyceride content ↔ White adipose tissue (HFD) Relative weight ↔