AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations by Jih-Luh.

Slides:

Advertisements

Similar presentations

RNA and Protein Synthesis

Advertisements

1 Gene – Expression – Mutation - polymorphism. 2 How are genes expressed ? Nucleus Cytoplasm DNA Transcription Poly(A ) Cap Pre-mRNA Splicing Cap Poly(A)

Chapter 13. The Central Dogma of Biology: RNA Structure: 1. It is a nucleic acid. 2. It is made of monomers called nucleotides 3. There are two differences.

Mutations Gene Mutations Change in the nucleotide sequence of a gene May only involve a single nucleotide May be due to copying errors, chemicals, viruses,

13-3 Mutations Can be good, bad or nothing!!. What is a mutation? The word is Latin for “to change”. There are 2 types: – 1) Single gene changes – 2)

12/16/14 StarterConnection/Exit: What is the true meaning of the word mutation? Are mutations bad / harmful? 12/16/14 Protein Synthesis Writing

Protein Synthesis- the ”Stuff of Life“ Translation- Making the Protein.

Point Mutations Silent Missense Nonsense Frameshift.

Mutations in DNA changes in the DNA sequence that can be inherited can have negative effects (a faulty gene for a trans- membrane protein leads to cystic.

Protein Synthesis Transcription and Translation RNA Structure Like DNA, RNA consists of a long chain of nucleotides 3 Differences between RNA and DNA:

 BUILD-A-BUG ACTIVITY  Build your bug and turn in to your box  Mutations Notes  Mutations practice QUIZ NEXT CLASS: Transcription and Translation TUESDAY.

Mutation. What you need to know How alteration of chromosome number or structurally altered chromosomes can cause genetic disorders How point mutations.

A change in the nucleotide sequence of DNA Ultimate source of genetic diversity Gene vs. Chromosome.

Genetic Code and Interrupted Gene Chapter 4. Genetic Code and Interrupted Gene Aala A. Abulfaraj.

Protein Synthesis. One Gene – One Enzyme Protein Synthesis.

Association between the diagnosis-to-treatment interval and overall survival in Taiwanese patients with oral cavity squamous cell carcinoma Chun-Ta Liao,

Volume 388, Issue 10058, Pages (November 2016)

DNA/GENE MUTATIONS.

Gene Mutations.

Factor VII-Induced MicroRNA-135a Inhibits Autophagy and Is Associated with Poor Prognosis in Hepatocellular Carcinoma Kuang-Tzu Huang, I-Ying Kuo, Ming-Chao.

Gene Mutations.

Types of Mutations.

Protein-Truncation Mutations in the RP2 Gene in a North American Cohort of Families with X-Linked Retinitis Pigmentosa Alan J. Mears, Linn Gieser, Denise.

DNA and mutations SC.912.L.16.4.

The superiority of haploidentical related stem cell transplantation over chemotherapy alone as postremission treatment for patients with intermediate-

Gene – Expression – Mutation - polymorphism

Diamond-Blackfan anemia: erythropoiesis lost in translation

Mutations of Chk2 in primary hematopoietic neoplasms

Gupta V, Tallman MS, Weisdorf DJ

Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value by Saman.

by Mario Cazzola, Marianna Rossi, and Luca Malcovati

The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in Africans with the Rh D-negative blood group phenotype.

High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric.

Functional features of RUNX1 mutants in acute transformation of chronic myeloid leukemia and their contribution to inducing murine full-blown leukemia.

Mutations changes in the DNA sequence that can be inherited

Rapid Assessment of the Heterogeneous Methylation Status of CEBPA in Patients with Acute Myeloid Leukemia by Using High-Resolution Melting Profile Tsung-Chin.

Predictive Factors For Do-Not-Resuscitate Designation Among Terminally Ill Cancer Patients Receiving Care From a Palliative Care Consultation Service

Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia by Jose Roman-Gomez, Antonio.

High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia by.

The immunophenotype of 177 adults with acute myeloid leukemia: proposal of a prognostic score by Ollivier Legrand, Jean-Yves Perrot, Marion Baudard, Annie.

A: OAZ1 mRNA transcript of 775-1, and parental cell lines showing the stop codon introduced by the nonsense mutations in the and transcripts,

Mutations Any change in an organism’s DNA. Mutations in somatic cells only impact individual; mutations in gametes may impact offspring. 2 Types: A. Gene.

EML4-ALK Translocation Predicts Better Outcome in Lung Adenocarcinoma Patients with Wild-Type EGFR Shang-Gin Wu, MD, Yao-Wen Kuo, MD, Yih-Leong Chang,

Objective Palliative Prognostic Score Among Patients With Advanced Cancer Yen-Ting Chen, MD, Chih-Te Ho, MD, Hua-Shai Hsu, MD, Po-Tsung Huang, MD, Chin-Yu.

Decitabine before Low-Dose Cytarabine-Based Chemotherapy Combined with Human Leukocyte Antigen–Mismatched Stem Cell Microtransplantation Improved Outcomes.

Pharmacogenomic variability and anaesthesia

Cervical Papanicolaou Smears in Hematopoietic Stem Cell Transplant Recipients: High Prevalence of Therapy-Related Atypia during the Acute Phase Shan-Chi.

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment Response in Advanced Lung Adenocarcinomas with G719X/L861Q/S768I Mutations Chao-Hua.

Overall survival by SCT versus observation in first complete remission

Comparison of the 6th and 7th Editions of the American Joint Committee on Cancer Tumor-Node-Metastasis Staging System in Patients With Resected Esophageal.

A 4-lncRNA scoring system for prognostication of adult myelodysplastic syndromes by Chi-Yuan Yao, Ching-Hsuan Chen, Huai-Hsuan Huang, Hsin-An Hou, Chien-Chin.

Phase II Randomized Trial of Erlotinib or Vinorelbine in Chemonaive, Advanced, Non- small Cell Lung Cancer Patients Aged 70 Years or Older Yuh-Min Chen,

Mutation Notes.

Different Efficacies of Erlotinib and Gefitinib in Taiwanese Patients with Advanced Non- small Cell Lung Cancer: A Retrospective Multicenter Study Wen-Chien.

Volume 151, Issue 3, Pages e1 (September 2016)

(A) yellow cDNA comparison among wild-type and ch mutants

Bcl-2-Like Protein 11 Deletion Polymorphism Predicts Survival in Advanced Non–Small- Cell Lung Cancer Jih-Hsiang Lee, MD, Yu-Lin Lin, MD, Wei-Hsun Hsu,

Survival based on V gene mutation status and CD38 expression among B-CLL patients who stratify to the Rai intermediate risk category. Survival based on.

Mutations: Changes in Genes

KIT mutations in GISTs. A, amino acid sequence of KIT exon 11 mutations in clinical GIST biopsies. –, amino acids that are deleted; italicized amino acids,

Gene Mutations.

by Jan J. Cornelissen, and Didier Blaise

Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and.

How I treat T-cell acute lymphoblastic leukemia in adults

Presentation transcript:

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations by Jih-Luh Tang, Hsin-An Hou, Chien-Yuan Chen, Chieh-Yu Liu, Wen-Chien Chou, Mei-Hsuan Tseng, Chi-Fei Huang, Fen-Yu Lee, Ming-Chih Liu, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu, Shang-Ju Wu, Woei Tsay, Yao-Chang Chen, Liang-In Lin, and Hwei-Fang Tien Blood Volume 114(26):5352-5361 December 17, 2009 ©2009 by American Society of Hematology

Patterns and locations of the 68 RUNX1 mutations, including 63 distinct and 5 insignificant mutations. Patterns and locations of the 68 RUNX1 mutations, including 63 distinct and 5 insignificant mutations. Four kinds of mutations were demonstrated: missense mutations, nonsense mutations, frameshift mutations, and in-frame mutations. Three kinds of frameshift mutations are noted: truncated mutations with defective RHD, truncated mutations with intact RHD, and elongated mutations with intact RHD. The numbering of nucleotide of transcript is according to the mRNA sequence from GenBank42 accession number D43968 (AML1b); on the other hand, the numbering of amino acid of protein is according to the amino acid sequence from GenBank accession number Q01196. G42R, D317N, Q370R, V425G, and M439L are insignificant mutations. ▴ and | represent the sites of mutation; X, the site of the stop codon; Ω, the site of insertion; and (hyphenated line), the site of deletion. RD indicates repression domain; E, exon; I, intron; nt, nucleotide; UTR, untranslated region; and a.a., amino acid. Jih-Luh Tang et al. Blood 2009;114:5352-5361 ©2009 by American Society of Hematology

Kaplan-Meier survival curves according to RUNX1 mutation status. Kaplan-Meier survival curves according to RUNX1 mutation status. (A-B) A total of 330 AML patients receiving standard chemotherapy. (C-D) Those patients with normal karyotype. Data are shown for OS (A,C) and DFS (B,D). Tick marks represent patients whose data were censored at the last time they were known to be alive (A) or in CR (B) or at the time of HSCT. Jih-Luh Tang et al. Blood 2009;114:5352-5361 ©2009 by American Society of Hematology