Volume 18, Issue 3, Pages (September 2013)

Slides:

Advertisements

Similar presentations

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

Advertisements

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Adiponectin Is Required for PPARγ-Mediated Improvement of Endothelial Function in Diabetic Mice Wing Tak Wong, Xiao Yu Tian, Aimin Xu, Jun Yu, Chi Wai.

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase Simon A. Hawley, David A. Pan, Kirsty J.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors Joan Sanchez-Gurmaches, Chien-Min.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling Gregory R. Steinberg, Belinda J. Michell,

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Metabolic Basis of Pulmonary Arterial Hypertension Gopinath Sutendra, Evangelos D. Michelakis Cell Metabolism Volume 19, Issue 4, Pages (April.

Lipin-1 Regulates Autophagy Clearance and Intersects with Statin Drug Effects in Skeletal Muscle Peixiang Zhang, M. Anthony Verity, Karen Reue Cell Metabolism.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Oxygen Sensors at the Crossroad of Metabolism Julián Aragonés, Peter Fraisl, Myriam Baes, Peter Carmeliet Cell Metabolism Volume 9, Issue 1, Pages

Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults B. Oelrich, A. Dewell,

Volume 26, Issue 2, Pages e2 (August 2017)

Effects of Extended-Release Niacin Added to Simvastatin/Ezetimibe on Glucose and Insulin Values in AIM-HIGH Ronald B. Goldberg, MD, Vera A. Bittner,

One Strike against Low-Carbohydrate Diets

Lymphatics as a New Active Player in Reverse Cholesterol Transport

Volume 14, Issue 2, Pages (August 2011)

Ghrelin—a new player in glucose homeostasis?

Jochen G. Schneider, Joseph H. Nadeau Cell Metabolism

Metabolism by Remote Control

Does Hypothalamic Inflammation Cause Obesity?

In and Out: Adipose Tissue Lipid Turnover in Obesity and Dyslipidemia

Mrap2: An Accessory Protein Linked to Obesity

Volume 13, Issue 1, Pages 5-6 (January 2011)

Volume 24, Issue 3, Pages (September 2016)

Safia Costes, Peter C. Butler Cell Metabolism

A Clock Ticks in Pancreatic β Cells

Volume 15, Issue 1, Pages (January 2012)

Assessment of Feeding Behavior in Laboratory Mice

Volume 23, Issue 3, Pages (March 2016)

Volume 17, Issue 5, Pages (May 2013)

Volume 13, Issue 1, Pages 5-6 (January 2011)

Volume 26, Issue 5, Pages e3 (November 2017)

Insulin biosynthesis: The IREny of it all

Treating Obesity? It's in the Bag!

Selective versus Total Insulin Resistance: A Pathogenic Paradox

One Strike against Low-Carbohydrate Diets

Autophagy: A Potential Link between Obesity and Insulin Resistance

The Osteoclast—Not Always Guilty

IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

The Stunned β Cell: A Brief History

Leucing Weight with a Futile Cycle

Beyond Energy Homeostasis: the Expanding Role of AMP-Activated Protein Kinase in Regulating Metabolism David Carling, Benoit Viollet Cell Metabolism

Volume 17, Issue 5, Pages (May 2013)

In and Out: Adipose Tissue Lipid Turnover in Obesity and Dyslipidemia

Volume 26, Issue 2, Pages e2 (August 2017)

Volume 25, Issue 4, Pages e4 (April 2017)

Volume 8, Issue 2, Pages (August 2008)

Volume 18, Issue 3, Pages (September 2013)

Volume 368, Issue 9541, Pages (September 2006)

Volume 14, Issue 2, Pages (August 2011)

Linking DNA Damage, NAD+/SIRT1, and Aging

An IRKO in the Podo: Impaired Insulin Signaling in Podocytes and the Pathogenesis of Diabetic Nephropathy Susan B. Gurley, Thomas M. Coffman Cell Metabolism

Volume 26, Issue 5, Pages e3 (November 2017)

Volume 3, Issue 1, Pages (January 2006)

Adiponectin: Starving for Attention

Volume 61, Issue 1, Pages (January 2002)

Hap1 and GABA: Thinking about food intake

Macrophage Metabolism Shapes Angiogenesis in Tumors

Volume 24, Issue 1, Pages 7-8 (July 2016)

Of Mice and Men: Not ExAKTly the Same?

AMPK and p53 help cells through lean times

Estrogens and Obesity: Is It All in Our Heads?

Watch the Clock, Not the Scale

Presentation transcript:

Volume 18, Issue 3, Pages 333-340 (September 2013) The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes Gregory Gaich, Jenny Y. Chien, Haoda Fu, Leonard C. Glass, Mark A. Deeg, William L. Holland, Alexei Kharitonenkov, Thomas Bumol, Holger K. Schilske, David E. Moller Cell Metabolism Volume 18, Issue 3, Pages 333-340 (September 2013) DOI: 10.1016/j.cmet.2013.08.005 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Trial Profile Numbers of subjects initially screened and subsequently randomized to each of four treatment groups are depicted. Subject disposition (number of subjects who discontinued treatment or completed the study) are also shown. Cell Metabolism 2013 18, 333-340DOI: (10.1016/j.cmet.2013.08.005) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Effect of LY2405319 on Triglycerides and LDL-Cholesterol Time course of mean (±SEM) change from baseline in fasting plasma TGs (A) and LDL-C (B). ∗p < 0.05 from baseline, †p < 0.05 from placebo. Cell Metabolism 2013 18, 333-340DOI: (10.1016/j.cmet.2013.08.005) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 3 Effect of LY2405319 on Body Weight and Selected Metabolic Parameters Mean change from baseline (±SEM) in fasting glucose, insulin, adiponectin, and body weight. ∗p < 0.05 from baseline, and †p < 0.05 from placebo. Cell Metabolism 2013 18, 333-340DOI: (10.1016/j.cmet.2013.08.005) Copyright © 2013 Elsevier Inc. Terms and Conditions