Figure 2 Haematoxylin and eosin staining

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Figure 2 Haematoxylin and eosin staining of different histological patterns of anaplastic thyroid carcinoma Figure 2 | Haematoxylin and eosin staining of different histological patterns of anaplastic thyroid carcinoma. a | Neoplastic cells with a spindled and pleomorphic giant pattern. Lymphocytic infiltration is present in the stroma (indicated by the arrows; ×20). b | Neoplastic cells with a pleomorphic giant cell pattern (×20). c | The presence of extensive tumour necrosis (indicated by the arrows; ×10). d | Atypical mitotic figure (tripolar mitosis is indicated by the arrow; ×40). e | Entrapped non-neoplastic thyroid follicles (indicated by the arrows; ×20). f | Anaplastic thyroid carcinoma (ATC) with adjacent differentiated papillary thyroid carcinoma (PTC) (indicated by the arrows; ×20). g | ATC with an adjacent component of poorly differentiated thyroid carcinoma (PDTC) (indicated by the arrows; ×20). h,i | Different regions of ATC with tumour-associated macrophages (TAMs) (×20), highlighted with immunohistochemical staining using anti‑CD68 antibody (×40). Molinaro, E. et al. (2017) Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies Nat. Rev. Endocrinol. doi:10.1038/nrendo.2017.76