Fixed drug eruption caused by dimenhydrinate

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Presentation transcript:

Fixed drug eruption caused by dimenhydrinate Sophia Giatrakou, MD, Evangelia Papadavid, MD, PhD, Dimitrios Kalogeromitros, MD, PhD, Konstandinos Theodoropoulos, MD, Eugenia Toumbis-Ioannou, MD, PhD, Michalis Makris, MD, PhD, Nikolaos G. Stavrianeas, MD, PhD Journal of the American Academy of Dermatology Volume 64, Issue 3, Pages 608-610 (March 2011) DOI: 10.1016/j.jaad.2009.07.001 Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Skin lesions of patient after oral provocation test. Diagnosis of fixed drug eruption from dimenhydrinate was confirmed. Journal of the American Academy of Dermatology 2011 64, 608-610DOI: (10.1016/j.jaad.2009.07.001) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Lesion resolved in approximately 20 days with application of topical steroid cream, and had not recurred at time of our writing. Journal of the American Academy of Dermatology 2011 64, 608-610DOI: (10.1016/j.jaad.2009.07.001) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 CD8– T cells in skin lesions became reactivated after re-exposure to causative drug, documented with immunostaining using anti-CD8. (Hematoxylin counter stain; original magnification: ×40.) Journal of the American Academy of Dermatology 2011 64, 608-610DOI: (10.1016/j.jaad.2009.07.001) Copyright © 2009 American Academy of Dermatology, Inc. Terms and Conditions