Surgical quality of wedge resection affects overall survival in patients with early stage non–small cell lung cancer Gaurav S. Ajmani, MHS, Chi-Hsiung.

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Presentation transcript:

Surgical quality of wedge resection affects overall survival in patients with early stage non–small cell lung cancer Gaurav S. Ajmani, MHS, Chi-Hsiung Wang, PhD, Ki Wan Kim, MD, John A. Howington, MD, Seth B. Krantz, MD The Journal of Thoracic and Cardiovascular Surgery Volume 156, Issue 1, Pages 380-391.e2 (July 2018) DOI: 10.1016/j.jtcvs.2018.02.095 Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Cohort selection from the National Cancer Database non–small cell lung cancer (NSCLC) participant user file. NSC, Non–small cell; CT, chemotherapy; RT, radiation therapy; SBRT, stereotactic body radiation therapy. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 380-391.e2DOI: (10.1016/j.jtcvs.2018.02.095) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Wedge resection quality and overall survival from diagnosis according to: (A) number of lymph nodes (LNs) examined, (B) margin status, and (C) overall surgical quality combining LNs examined and margin status. Results are presented as Kaplan–Meier curves with 95% confidence interval bands. R0, Negative margins; R1/R2, positive margins. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 380-391.e2DOI: (10.1016/j.jtcvs.2018.02.095) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 SBRT compared with wedge resection and overall survival from diagnosis, among the propensity-matched cohort: (A) overall and (B) according to overall surgical quality combining nodes examined and margin status. Results are presented as Kaplan–Meier curves with 95% confidence interval bands. SBRT, Stereotactic body radiation therapy; R0, negative margins; R1/R2, positive margins; LN, lymph node. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 380-391.e2DOI: (10.1016/j.jtcvs.2018.02.095) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 A, Standardized difference plot, and (B) mirror histogram showing subcohort balance after propensity score-matching. SCC, Squamous cell carcinoma; L, left; R, right; SES, socioeconomic status; AC, adenocarcinoma; BAC, bronchoalveolar carcinoma. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 380-391.e2DOI: (10.1016/j.jtcvs.2018.02.095) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Wedge resection quality and survival versus stereotactic radiation. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 380-391.e2DOI: (10.1016/j.jtcvs.2018.02.095) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Video 1 Dr Krantz discussing the background and relevance of the study. Video available at: http://www.jtcvsonline.org/article/S0022-5223(18)30776-1/fulltext. The Journal of Thoracic and Cardiovascular Surgery 2018 156, 380-391.e2DOI: (10.1016/j.jtcvs.2018.02.095) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

The Journal of Thoracic and Cardiovascular Surgery 2018 156, 380-391 The Journal of Thoracic and Cardiovascular Surgery 2018 156, 380-391.e2DOI: (10.1016/j.jtcvs.2018.02.095) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions