What does this protein make up or do? Chapter 11: Chromosome 11 DNA Sequence Chromosome 4888 bp Name of Protein 11 Name of Gene polyalanine PHOX2B transcription Amino acid sequence mRNA 314 aa translation Cytoplasm A Cell Nucleus What does this protein make up or do? Helps form nerve cells during early development Condition/Disease Neuroblastoma

Description of Neuroblastoma Symptoms and characteristics Neuroblastoma is one of the few human malignancies known to demonstrate spontaneous regression from an undifferentiated state to a completely benign cellular appearance. It is a disease exhibiting extreme heterogeneity, and is stratified into three risk categories: low, intermediate, and high risk. Low-risk disease is most common in infants and good outcomes are common with observation only or surgery, whereas high-risk disease is difficult to treat successfully even with the most intensive multi-modal therapies available Normal Vision As viewed by a person with glaucoma Pictures used with permission from URL: http://www.nei.nih.gov/health/glaucoma/glaucoma_facts.asp

Description of Neuroblastoma (cont.) Who is affected? Everyone, as it is a cancer, but it is sporadic and unpredictable so far Outlook or quality of life It is a severe cancer, so the outlook of life can be compared to that of a breast cancer patient. This means multiple surgeries and types of therapy. These are both expensive and take a very long time to recover from. Researcher: BB

References NCBI. Genes and Disease: Glaucoma [online]. 2003. [cited 2004 July 14]. Available at URL: http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.127. NCBI. Entrez [online]. 2003. [cited 2004 July 14]. Available at URL: http://www.ncbi.nih.gov/Entrez/. National Eye Institute. Glaucoma: What you should know [online]. 2004. [cited July 14]. Available at URL: http://www.nei.nih.gov/health/glaucoma/glaucoma_facts.asp.