Epigenetic features of the mouse trophoblast Peter J. Rugg-Gunn  Reproductive BioMedicine Online  Volume 25, Issue 1, Pages 21-30 (July 2012) DOI: 10.1016/j.rbmo.2012.01.012 Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Critical roles of epigenetic modifiers during development of the mouse trophoblast lineage from the outer layer of E3.5 blastocysts to specialization within the E12.5 fetal placenta. The tissue sources of trophoblast stem cells (TSC) and embryonic stem cells (ESC) are indicated. Genes listed below the timeline provide examples of epigenetic modifiers that have important functions at different stages of trophoblast development. Question marks indicate genes that require further functional data to confirm their roles in trophoblast regulation. 5hmC=5-hydroxymethylcytosine; 5mC=DNA methyltransferase; HAT=histone acetyltransferase; HDAC=histone deacetylase; HMT=histone methyltransferase. This figure is adapted from Rossant and Cross (2001) and Hemberger (2007). Reproductive BioMedicine Online 2012 25, 21-30DOI: (10.1016/j.rbmo.2012.01.012) Copyright © 2012 Reproductive Healthcare Ltd. Terms and Conditions