Effect of vitamin E supplementation with and without hormone therapy on circulatory inflammatory markers in postmenopausal women Bruce R. Carr, M.D.,

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Presentation transcript:

Effect of vitamin E supplementation with and without hormone therapy on circulatory inflammatory markers in postmenopausal women Bruce R. Carr, M.D., Naveed Khan, M.D., Beverley Adams-Huet, M.S., Nirupama Kakarla, M.D., Jon C. Havelock, Jennifer Gell, M.D. Fertility and Sterility Volume 85, Issue 3, Pages 667-673 (March 2006) DOI: 10.1016/j.fertnstert.2005.08.030 Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Flow of patients through the trial. AT = α-tocopherol, CEE = conjugated equine estrogens, CEE + MPA = conjugated equine estrogens plus medroxyprogesterone acetate. Carr. Vitamin E and HT on cardiovascular markers. Fertil Steril 2006. Fertility and Sterility 2006 85, 667-673DOI: (10.1016/j.fertnstert.2005.08.030) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 The effect of α-tocopherol (vitamin E), 400 IU/day, and hormone therapy on serum α-tocopherol (AT) levels. Placebo (AT alone), CEE (conjugated equine estrogens – Premarin 0.625 mg) and CEE + MPA (conjugated equine estrogens and medroxyprogesterone acetate – PREMPRO, 0.625/2.5 mg.) All groups received AT from week 0 to week 4. From week 4 to week 12 they received either AT with or without CEE or CEE +MPA. Values represent mean ± standard deviation. †P<.001 compared with baseline (week 0). *P<.05. **P<.01, week 4 versus week 12. Carr. Vitamin E and HT on cardiovascular markers. Fertil Steril 2006. Fertility and Sterility 2006 85, 667-673DOI: (10.1016/j.fertnstert.2005.08.030) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions