Inflammation and post-operative recovery in patients undergoing total knee arthroplasty- secondary analysis of a randomized controlled trial A. Langkilde,

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Inflammation and post-operative recovery in patients undergoing total knee arthroplasty- secondary analysis of a randomized controlled trial A. Langkilde, T.L. Jakobsen, T.Q. Bandholm, J. Eugen-Olsen, T. Blauenfeldt, J. Petersen, O. Andersen Osteoarthritis and Cartilage Volume 25, Issue 8, Pages 1265-1273 (August 2017) DOI: 10.1016/j.joca.2017.03.008 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow chart over study. Osteoarthritis and Cartilage 2017 25, 1265-1273DOI: (10.1016/j.joca.2017.03.008) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Plasma levels of the inflammatory markers IP-10, suPAR, IL-6, IL-10 and TNF-α during the study. The x-axis marks the times for blood sampling: Incl: sample taken at study inclusion; Op: immediately before TKA; Day 1: The day after TKA; week 4, 8, and 26: 4, 8, and 26 weeks after TKA. The lines depict the mean of the progressive strength training (PST) group in black, of the control (CON) group in grey, and the mean of all subjects in red. Dotted lines depict 95% confidence intervals. Red lines with * show a significant change between baseline and all other times; day 1 and week 4; week 4 and week 8, and 26; and week 8 and 26 when all subjects are grouped. Osteoarthritis and Cartilage 2017 25, 1265-1273DOI: (10.1016/j.joca.2017.03.008) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Ex vivo model of inflammatory responses. Whole blood from healthy donors was stimulated with suPAR (s100 = 100 ng/mL suPAR; s300 = 300 ng/mL suPAR), TNF-α, IL-10, and a mixture of lipopolysaccharide and phytohaemagglutinin (LPS + PHA-L) for 3, 6 and 24 h; and the induction of IL-6, IL-10, IP-10, and TNF-α was measured compared to a negative control. The dotted line marks a ratio of 1 representing no inflammatory response. Each donor is represented with a unique symbol. *: a response significantly different from the negative control (P < 0.01); **: a response significantly different from the 3 h hour response (<0.01); ***: a response significantly different from the 6 h hour response (<0.01). Only the 6 h response was measured for one of the donors. Osteoarthritis and Cartilage 2017 25, 1265-1273DOI: (10.1016/j.joca.2017.03.008) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions