ESL of mesenteric microvessels is compromised in old MWF rats.

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ESL of mesenteric microvessels is compromised in old MWF rats. ESL of mesenteric microvessels is compromised in old MWF rats. Confocal microscopy images of FITC-WGA lectin (green) labeling ESL (esl), alongside simultaneous DIC imaging of microvessel anatomy in a healthy young MWF rat (A and B) and an old MWF rat (C and D). Linear labeling of ESL at the vessel margin in a young MWF rat (Ai and Aii) is removed by neuraminidase (Bi and Bii). ESL is not apparent in mesenteric microvessels of old MWF rats before (Ci and Cii) or after (Di and Dii) neuraminidase. Under baseline conditions (open bars), ESL covers most of wall of mesenteric microvessels (E), and is approximately 0.6 µm deep (F), in healthy rats (old Wistar rats, n=111 vessels in 3 rats; young MWF rats, n=47 vessels in 3 rats). ESL coverage and depth are both reduced by neuraminidase (black bar) in these healthy rats. In contrast, ESL is significantly sparser (E) and shallower (F) in old MWF rats under baseline conditions (n=165 vessels in 4 rats), and is not reduced any further by neuraminidase. *P<0.05 versus both healthy rat groups (one-way ANOVA, Bonferroni); #P<0.05 versus baseline values (one-way ANOVA, Bonferroni); ns, not significant versus preneuraminidase values (one-way ANOVA, Bonferroni). esl, ESL; vl, vessel lumen; i, interstitium; vw, vessel wall. Scale bar, 10 microns. Andrew H.J. Salmon et al. JASN 2012;23:1339-1350 ©2012 by American Society of Nephrology