Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II Mihaela Teodorescu,

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Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II Mihaela Teodorescu, MD, MS, Oleg Broytman, PhD, Douglas Curran-Everett, PhD, Ronald L. Sorkness, PhD, Gina Crisafi, BS, Eugene R. Bleecker, MD, Serpil Erzurum, MD, Benjamin M. Gaston, MD, Sally E. Wenzel, MD, Nizar N. Jarjour, MD The Journal of Allergy and Clinical Immunology: In Practice Volume 3, Issue 4, Pages 566-575.e1 (July 2015) DOI: 10.1016/j.jaip.2015.04.002 Copyright © 2015 Terms and Conditions

Figure 1 Sputum eosinophils and PMNs (expressed as percentage of sputum total white blood cell counts) in asthmatic subjects with and without high OSA risk (defined as scores on Sleep Apnea scale of the Sleep Disorders Questionnaire [SA-SDQ] ≥ 36 for men and ≥32 for women). In subjects with high OSA risk compared with those without high OSA, there were higher % PMNs, whereas % sputum eosinophils were similar between the 2 groups. *P value = .001 (2-sample Student t-test). OSA, Obstructive sleep apnea; PMNs, polymorphonuclear neutrophils. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 566-575.e1DOI: (10.1016/j.jaip.2015.04.002) Copyright © 2015 Terms and Conditions

Figure 2 Proportion of sputum inflammatory phenotypes in asthmatic subjects with and without high OSA risk (defined as scores on Sleep Apnea scale of the Sleep Disorders Questionnaire [SA-SDQ] ≥ 36 for men and ≥32 for women). Asthmatic subjects with high OSA risk, compared with those without high OSA risk, tended to have higher proportions of neutrophilic and mixed granulocytic, and lower proportions of eosinophilic and paucigranulocytic phenotypes (P = .06, Fisher's exact test). OSA, obstructive sleep apnea. The Journal of Allergy and Clinical Immunology: In Practice 2015 3, 566-575.e1DOI: (10.1016/j.jaip.2015.04.002) Copyright © 2015 Terms and Conditions