Figure6.1 Codon-anticodon interactions. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.2 Genome of a simian virus 40 (SV40). Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.3 Interaction of a tRNA with its aminoacyl-tRNA synthetase. Adapted from Perona, J., Rould, M., and Steitz, T. Biochemistry. 32:8758, 1993. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.4 Model of ribosome structure and functional sites.. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.5 Crystallographic structure of a 70 S ribosome. Reprinted with permission from Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H. D., and Noller, H. F. Science 292:883, 2001. Reprinted with permission from AAAS. Figure generously supplied by Drs. A. Baucom and H. Noller. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.6 Electron-micrographs of polysomes. Courtesy of Dr. Alex Rich, M.I.T.. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.7 Initiation of translation in eukaryotes. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.8a Elongation steps in protein synthesis. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.8b Elongation steps in eukaryotic protein synthesis.. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.9 EF1 in the elongation cycle. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.10 Termination of translation.. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.11 Puromycin (bottom) terminates translation by binding at the large subunit A site and acting as an analog of aminoacyl-tRNA (here tyrosyl-tRNA [top]). Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.12 Rough endoplasmic reticulum. Courtesy of Dr. U. Jarlfors, University of Miami. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.13 Secretory pathway: signal-peptide recognition. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.14 Biosynthesis of N-linked oligosaccharides at the surface of the endoplasmic reticulum. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.15 Structure of N-linked oligosaccharides.. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.16 Examples of oligosaccharide structure. Adapted from Paulson, J. Trends in Biochem. Sci. 14:272, 1989. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.17 Targeting of enzymes to lysosomes. Adapted from Kornfeld, R., and Kornfeld, S. Annu. Rev. Biochem. 54:631, 1985.. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.18 Topology of proteins at membranes of endoplasmic reticulum. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.19 Maturation of human proinsulin. Redrawn from Bell, G.I., Swain, W.F., Pictet, R., Codell, B., Goodsman, H.M., and Rutter, W. J Nature 282:525, 1979. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.20 Diphthamide (top left) is a postranslational modification of a specific residue of histidine (top right) in EF2. (bottom) ADP ribosyl diphthamide.. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.21 Collagen structure, illustrating (bottom to top) the regularity of primary sequence in a left-handed polyproline type II helix; the right-handed triple helix; the 300-nm molecule; and the organization of molecules in a typical fibril, within which collagen molecules are cross-linked. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.22 Model of the proteasome. Adapted from Rubin, D., and Finley, D. Cur. Biol. 5:854, 1995; and Peters, J.-M. Trends Biochem. Sci. 19:377, 1994. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.

Figure 6.23 ATP and ubiquitin-dependent protein degradation. Textbook of Biochemistry with Clinical Correlations, 7e edited by Thomas M. Devlin © 2011 John Wiley & Sons, Inc.