B-cell Signaling: Protein Kinase Cδ Puts the Brakes on

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B-cell Signaling: Protein Kinase Cδ Puts the Brakes on Diane Mathis, George L King  Current Biology  Volume 12, Issue 16, Pages R554-R556 (August 2002) DOI: 10.1016/S0960-9822(02)01052-7

Figure 1 Different signals emanating from the B cell antigen receptor. Left, events downstream of an activation stimulus (e.g. a foreign antigen). Right, events downstream of a tolerogenic stimulus (such as a soluble self-antigen). The upper curve represents the plasma membrane, and the inner represents the nuclear membrane. Ca2+ depicts the calcium signal, with the size of the triangle reflecting the strength and duration of this signal. ERK, extracellular signal regulated kinase; JNK, c-Jun N-terminal kinase; NFAT, nuclear factor of activated T cells; NFκB, nuclear factor κB. Current Biology 2002 12, R554-R556DOI: (10.1016/S0960-9822(02)01052-7)